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    CAS No. 148-03-8 Price
    Catalog No.CFN96393Purity>=98%
    Molecular Weight416.7Type of CompoundPhenols
    FormulaC28H48O2Physical DescriptionOil
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Beta-Tocopherol Description
    Source: The seeds of Sunflower.
    Biological Activity or Inhibitors: 1. Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.
    2. Beta-Tocopherol shows a slight time dependency inhibition on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3998 mL 11.999 mL 23.9981 mL 47.9962 mL 59.9952 mL
    5 mM 0.48 mL 2.3998 mL 4.7996 mL 9.5992 mL 11.999 mL
    10 mM 0.24 mL 1.1999 mL 2.3998 mL 4.7996 mL 5.9995 mL
    50 mM 0.048 mL 0.24 mL 0.48 mL 0.9599 mL 1.1999 mL
    100 mM 0.024 mL 0.12 mL 0.24 mL 0.48 mL 0.6 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Beta-Tocopherol References Information
    Citation [1]

    Helia,2003,26 38):17-23.

    Identification and genetic characterization of new sources of beta- and gamma-tocopherol in sunflower germplasm[Reference: WebLink]
    Sunflower seeds have more than 90% of the total tocopherols in the form of alpha-tocopherol, which exerts a weak antioxidant protection of the extracted oil. A partial substitution of alpha-tocopherol by another tocopherol derivative with greater antioxidant action would improve the oxidative stability of sunflower oil. The objective of the present research was to identify sources of modified tocopherol profile in sunflower germplasm. A total of 952 germplasm accessions were evaluated by analyzing the tocopherol profile of 12 half-seeds per accession by HPLC. The screening resulted in the identification of a source of increased Beta-Tocopherol content and a source of increased gamma-tocopherol content. In both cases the accessions corresponded to old populations of Peredovick. The line T589 presented a Beta-Tocopherol content from 30.4 to 48.5% of the total tocopherols, whereas the line T2100 had a gamma-tocopherol content from 87.9 to 93.9%. Genetic studies revealed that both traits were partially recessive in crosses with material with standard tocopherol profile.
    Citation [2]

    J Nutr. 2009 Jun;139(6):1135-42.

    Dietary beta-tocopherol and linoleic acid, serum insulin, and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.[Pubmed: 19339706 ]
    Multivariate regression analyses showed that the PCA-extracted nutrient factor most heavily loaded with Beta-Tocopherol and linoleic acid (P = 0.03) was an independent positive predictor of serum SHBG. When individual nutrients were the predictor variables, Beta-Tocopherol (P = 0.002), but not other tocopherols or fatty acids (including linoleic acid), was an independent positive predictor of serum SHBG. Circulating insulin (P = 0.02) and waist circumference (P = 0.002), but not serum lipids, were negative independent predictors of SHBG in all regression models. Additional studies are needed in women of other age groups and men to determine whether consumption of foods rich in Beta-Tocopherol and/or linoleic acid may increase serum SHBG concentrations and may thereby decrease the risk for metabolic syndrome and reproductive organ cancer.
    Citation [3]

    Free Radic Biol Med. 2001 Jun 15;30(12):1381-9.

    Differential inhibition by α- and β-tocopherol of human erythroleukemia cell adhesion: role of integrins[Pubmed: 11390183]
    The effect of alpha- and Beta-Tocopherol on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA) has been studied. Adhesion induced by PMA stimulation was prevented by 44.5% by physiological concentrations of alpha-tocopherol. Under the same experimental conditions, Beta-Tocopherol, an analogue of alpha-tocopherol, produced 11% inhibition of adhesion. Cell response gradually increased from 0 to 24 h of alpha-tocopherol treatment. Only a slight time dependency of Beta-Tocopherol inhibition was observed. Another human erythroleukemia cell line (K562) and the human monocyte tumor cell line U937 showed 5.0 and 11.2% inhibition, respectively. Similar to alpha-tocopherol, the protein kinase C inhibitor, Calphostin C, and the MAPK inhibitor, PD98059, prevented PMA-induced cell adhesion. An inhibition of ERK-1 phosphorylation was observed for alpha-tocopherol only in HEL, implying that MAP kinase pathway is involved in this cell line. Fluorescence-activated cell sorting (FACS), by using various integrin-specific monoclonal antibodies, has shown that alpha (1-6), beta1, and alphav integrins are less expressed at the cell surface after alpha-tocopherol treatment. Beta-Tocopherol treatment was less effective.