|Source:||The herbs of Caulophyllum robustum|
|Biological Activity or Inhibitors:||1. Cauloside A exhibits concentration- and time-dependent mitochondriotoxic activities.
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.6534 mL||8.2671 mL||16.5341 mL||33.0682 mL||41.3353 mL|
|5 mM||0.3307 mL||1.6534 mL||3.3068 mL||6.6136 mL||8.2671 mL|
|10 mM||0.1653 mL||0.8267 mL||1.6534 mL||3.3068 mL||4.1335 mL|
|50 mM||0.0331 mL||0.1653 mL||0.3307 mL||0.6614 mL||0.8267 mL|
|100 mM||0.0165 mL||0.0827 mL||0.1653 mL||0.3307 mL||0.4134 mL|
J Nat Prod. 2014 Jan 24;77(1):111-7.
|Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.[Pubmed: 24328138 ]|
|The potential link between mitochondrial disruption and idiosyncratic herbal intoxication prompted further examination. The C. thalictroides methanol extract and three saponins, Cauloside A (1), saponin PE (2), and cauloside C (3), exhibited concentration- and time-dependent mitochondriotoxic activities. Upon treatment, cell respiration rate rapidly increased and then dramatically decreased within minutes. Mechanistic studies revealed that C. thalictroides constituents impair mitochondrial function by disrupting membrane integrity. These studies provide a potential etiological link between this mitochondria-sensitive form of cytotoxicity and idiosyncratic organ damage.|
Zhong Yao Cai. 2012 Nov;35(11):1789-92.
|Chemical constituents of Dipsacus asper.[Pubmed: 23627090]|
|To study the chemical constituents of Dipsacus asper. METHODS: Column chromatography on Silica gel and RP-C18 were applied for isolation and purification of the constituents. Their structures were identified by spectral and chemical methods. RESULTS: From the crude MeOH fraction of Dipsacus asper, 12 compounds were isolated and identified as Sucrose (1), beta-sitosterol (2), Oleanic acid (3), Triplostoside A (4), Loganin (5), Loganin acid (6), Sweroside (7), Epi-vogeloside ( 8), Vogeloside (9), Akebiasaponin D(10), Cauloside A(11),7-Deoxyloganic acid (12). CONCLUSION: Compounds 8, 9, 12 are isolated from this plant for the first time.|