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    Cedrelopsin
    Cedrelopsin
    Information
    CAS No. 19397-28-5 Price
    Catalog No.CFN89410Purity>=98%
    Molecular Weight260.28Type of CompoundCoumarins
    FormulaC15H16O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Cedrelopsin Description
    Source: The trunk barks of Cedrelopsis grevei.
    Biological Activity or Inhibitors: 1. Cedrelopsin shows significant inhibition against A549 cells with IC50 values of 3.6-5.9 ug/mL.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.842 mL 19.2101 mL 38.4202 mL 76.8403 mL 96.0504 mL
    5 mM 0.7684 mL 3.842 mL 7.684 mL 15.3681 mL 19.2101 mL
    10 mM 0.3842 mL 1.921 mL 3.842 mL 7.684 mL 9.605 mL
    50 mM 0.0768 mL 0.3842 mL 0.7684 mL 1.5368 mL 1.921 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7684 mL 0.9605 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Cedrelopsin References Information
    Citation [1]

    Fitoterapia. 2003 Dec;74(7-8):638-42.

    New coumarins from Cedrelopsis grevei.[Pubmed: 14630167]
    Two new coumarins, 7-methoxy-5-prenylcoumarin (isoCedrelopsin) (1) and 3',4'-dihydrobraylin (2), were isolated from the trunk bark of Cedrelopsis grevei, along with five known coumarins, microfolicoumarin (6,7-dimethoxy-5-prenylcoumarin, (3), obliquin (4), 8-methoxyobliquin (5), aesculetin (6), Cedrelopsin (7) and scoparone (8).
    Citation [2]

    Medicinal Chemistry Research, 2016, 25(3):466-472.

    Cytotoxic constituents of Oldenlandia umbellata and isolation of a new symmetrical coumarin dimer.[Reference: WebLink]
    Chemical investigation of HUM-E and HUM-B resulted in the isolation of a novel symmetrical coumarin dimer named oledicoumarin (1), together with eleven known compounds, hedyotiscone B (2), Cedrelopsin (3), pheophorbide A methyl ester (4), deacetyl asperuloside (5), scandoside methyl ester (6), asperulosidic acid (7), scandoside (8), nicotinic acid (9), 6α-hydroxy geniposide (10) anthragallol 1,2-dimethyl ether (11) and anthragallol 1,3-dimethyl ether (12). All compounds were isolated for the first time from O. umbellata except anthragallols. This is the foremost report exploring the presence of coumarin derivatives in O. umbellata. Testing of cytotoxicity of isolated constituents revealed that compounds 3, 4, 11 and 12 showed significant inhibition against A549 cells with IC50 values of 3.6–5.9 μg/mL. Compounds 4, 11 and 12 showed marked inhibitory effect against MDA-MB-231 cells (IC50 3.6–9.1 μg/mL). Compounds 4 (IC50 1.7 μg/mL) and 7 (IC50 6.1 μg/mL) were highly active against HT-29 cells. In summary, the less polar fraction of O. umbellata and its constituents were found to be cytotoxic.