Science | Nature | Cell | View More
Natural Products
Chamazulene
Chamazulene
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Chamazulene
Price:
CAS No.: 529-05-5
Catalog No.: CFN70396
Molecular Formula: C14H16
Molecular Weight: 184.3 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Oil
Source: The herbs of Matricaria chamomilla L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Charles Sturt University (Denmark)
  • University of Sao Paulo (Brazil)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Toronto (Canada)
  • University of British Columbia (Canada)
  • University of Madras (India)
  • Research Unit Molecular Epigene... (Germany)
  • Kyushu University (Japan)
  • Universidad de Ciencias y Artes... (Mexico)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universidade Federal de Goias (... (Brazil)
  • More...
Package
Featured Products
Pinobanksin

Catalog No: CFN98917
CAS No: 548-82-3
Price: $338/5mg
Tormentic acid

Catalog No: CFN99434
CAS No: 13850-16-3
Price: $238/10mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Eurycomalactone

Catalog No: CFN92129
CAS No: 23062-24-0
Price: $358/10mg
Tricetin

Catalog No: CFN70392
CAS No: 520-31-0
Price: $118/10mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
L-Arginine

Catalog No: CFN90550
CAS No: 74-79-3
Price: $30/20mg
Sanguinarine

Catalog No: CFN98259
CAS No: 2447-54-3
Price: $30/20mg
Artepillin C

Catalog No: CFN70443
CAS No: 72944-19-5
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Chamazulene is an important factor for the antioxidant power of chamomile oil, it presents interesting properties concerning radical processes. Chamazulene may contribute to the anti-inflammatory activity of chamomile extracts by inhibiting the leukotriene synthesis and additional antioxidative effects.
In vitro:
Planta medica, 1994, 60(05):410-413.
Chamazulene: An Antioxidant-Type Inhibitor of Leukotriene B4 Formation.[Reference: WebLink]
Matricine and its transformation product Chamazulene are constituents of chamomile extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since preparations from chamomile are used for the treatment of inflammatory skin and bowel diseases, we studied the effects of these compounds on the leukotriene production in neutrophilic granulocytes.
METHODS AND RESULTS:
Chamazulene inhibited the formation of leukotriene B4 in intact cells and in the 105,000 × g supernatant fraction in a concentration-dependent manner. The IC50 values were 15 and 10 µM, respectively. Matricine showed no effect up to 200 µM. Chamazulene (IC50: 2 µM), but not matricine, blocked the chemical peroxidation of arachidonic acid. Additionally, matricine (up to 200 µM) had no effects on the cyclooxygenase and 12-lipoxygenase activities in human platelets.
CONCLUSIONS:
Therefore, it is concluded that Chamazulene, but not matricine, may contribute to the anti-inflammatory activity of chamomile extracts by inhibiting the leukotriene synthesis and additional antioxidative effects.
Research Communications in Molecular Pathology & Pharmacology, 1996, 92(3):361-364.
Investigation of the effect of chamazulene on lipid peroxidation and free radical processes.[Reference: WebLink]
Oxygen toxicity and related free radical reactions are implicated in numerous pathophysiological conditions, like atherosclerosis, inflammation, gastric ulceration, neuronal degeneration, tumour promotion. The flowers of Matricaria chamomilla, Asteraceae, have been used therapeutically for conditions in which oxidative stress is supposed to be implicated.
METHODS AND RESULTS:
We considered interesting to investigate the effect of Chamazulene, the active substance of chamomile, on free radical processes. Membrane lipid peroxidation was induced by Fe2+/ascorbate and assessed as the 2-thiobarbituric acid reactive material. The hydroxyl radical scavenging activity was studied as the competition of Chamazulene with DMSO for HO. generated by Fe3+/ascorbate. Finally, the interaction of Chamazulene with the N-centered stable free radical DPPH was estimated photometrically (517 nm). It was found that Chamazulene inhibited lipid peroxidation in a concentration and time dependent manner presenting an IC50 of 18 microM after 45 min incubation. It could also inhibit the autoxidation of DMSO (33 mM) by 76% at 25 mM, and had a weak capacity to interact with DPPH.
CONCLUSIONS:
In conclusion, Chamazulene presents interesting properties concerning radical processes.
Natural Product Research,2014, 28(24):2321-2323.
Antioxidant and radical scavenging activities of chamazulene.[Reference: WebLink]
Essential oils (EOs) of chamomile contain several bioactive compounds, including monoterpenes, sesquiterpenes, triterpenes and fatty acids. Hydrodistillation of chamomile EO induces the formation of Chamazulene, a bioactive compound.
METHODS AND RESULTS:
Chamazulene was isolated from the EO by column chromatography. The total antioxidant capacity confirmed a higher antioxidant activity of Chamazulene (IC50 = 6.4 μg mL(- 1)) than of ascorbic acid (IC50 = 12.8 μg mL(- 1)), α-tocopherol (IC50 = 20.5 μg mL(- 1)) and of butylated hydroxytoluene (BHT) (IC50 = 30.8 μg mL(- 1)). Chamazulene was unable to react with DPPH√. However, when Chamazulene was assayed with ABTS√, a strong and significantly (P < 0.05) higher free radical scavenging activity was observed (IC50 = 3.7 μg mL(- 1)), with respect to BHT (IC50 = 6.2 μg mL(- 1)) and α-tocopherol (IC50 = 11.5 μg mL(- 1)).
CONCLUSIONS:
The results of this work show that Chamazulene is an important factor for the antioxidant power of chamomile oil.
Chamazulene Description
Source: The herbs of Matricaria chamomilla L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Daucoidin A

Catalog No: CFN95275
CAS No: 103629-87-4
Price: $318/5mg
Schisphenin E

Catalog No: CFN95223
CAS No: 1311376-52-9
Price: $318/5mg
1-Methyl-2,8-dihydroxy-3-carboxy-9...

Catalog No: CFN95101
CAS No: 1401414-53-6
Price: $338/5mg
12beta-Acetoxy-3beta-hydroxy-7,11,...

Catalog No: CFN95468
CAS No: 1085338-75-5
Price: $318/5mg
Selina-4(15),7(11)-dien-8-one

Catalog No: CFN95078
CAS No: 54707-47-0
Price: $288/10mg
5-O-Coumaroylquinic acid

Catalog No: CFN95507
CAS No: 32451-86-8
Price: $318/5mg
Cichoriin

Catalog No: CFN95196
CAS No: 531-58-8
Price: $100/20mg
Cistantubuloside C1

Catalog No: CFN95121
CAS No: 620632-36-2
Price: $298/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.4259 mL 27.1297 mL 54.2594 mL 108.5187 mL 135.6484 mL
5 mM 1.0852 mL 5.4259 mL 10.8519 mL 21.7037 mL 27.1297 mL
10 mM 0.5426 mL 2.713 mL 5.4259 mL 10.8519 mL 13.5648 mL
50 mM 0.1085 mL 0.5426 mL 1.0852 mL 2.1704 mL 2.713 mL
100 mM 0.0543 mL 0.2713 mL 0.5426 mL 1.0852 mL 1.3565 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Pinobanksin

Catalog No: CFN98917
CAS No: 548-82-3
Price: $338/5mg
Tormentic acid

Catalog No: CFN99434
CAS No: 13850-16-3
Price: $238/10mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Eurycomalactone

Catalog No: CFN92129
CAS No: 23062-24-0
Price: $358/10mg
Tricetin

Catalog No: CFN70392
CAS No: 520-31-0
Price: $118/10mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
L-Arginine

Catalog No: CFN90550
CAS No: 74-79-3
Price: $30/20mg
Sanguinarine

Catalog No: CFN98259
CAS No: 2447-54-3
Price: $30/20mg
Artepillin C

Catalog No: CFN70443
CAS No: 72944-19-5
Price: $ / mg
Tags: buy Chamazulene | Chamazulene supplier | purchase Chamazulene | Chamazulene cost | Chamazulene manufacturer | order Chamazulene | Chamazulene distributor