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    Cochinchinenin A
    Cochinchinenin A
    Information
    CAS No. 221696-69-1 Price $358 / 20mg
    Catalog No.CFN90769Purity>=98%
    Molecular Weight286.3Type of CompoundChalcones
    FormulaC17H18O4Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    Cochinchinenin A Description
    Source: From Daemonorops draco Bl.
    Biological Activity or Inhibitors: 1. The combination of Cochinchinenin A, cochinchinenin B, and loureirin B is the material basis for the analgesic effect of Dragon’s Blood.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Cochinchinenin A References Information
    Citation [1]

    Science in China Series C June 2006, Volume 49, Issue 3, pp 274-285

    Modulation of dragon’s blood on tetrodotoxin-resistant sodium currents in dorsal root ganglion neurons and identification of its material basis for efficacy [Reference: WebLink]
    The effects of dragon’s blood and the combined effects of three components (Cochinchinenin A, cochinchinenin B, and loureirin B) extracted from dragon’s blood on the TTX-R sodium currents in acute-isolated DRG neurons of rats were observed.The effects of the combination of Cochinchinenin A, cochinchinenin B, and loureirin B were in good agreement with those of dragon’s blood.These results suggested that the interference with pain messages caused by the modulation of dragon’s blood on TTX-R sodium currents in DRG neurons may explain some of the analgesic effect of dragon’s blood and the corresponding material basis for the efficacy is the combination of Cochinchinenin A, cochinchinenin B, and loureirin B.
    Citation [2]

    Science in China Series C: Life Sciences November 2008, Volume 51, Issue 11, pp 1025-1038

    Material basis for inhibition of Dragon’s Blood on evoked discharges of wide dynamic range neurons in spinal dorsal horn of rats[Reference: WebLink]
    Extracellular microelectrode recordings were used to observe the effects of Dragon’s Blood and various combinations of the three components (Cochinchinenin A, cochinchinenin B, and loureirin B) extracted from Dragon’s Blood on the discharge activities of wide dynamic range (WDR) neurons in spinal dorsal horn (SDH) of intact male Wistar rats evoked by electric stimulation at sciatic nerve. Only the combined effect of Cochinchinenin A, cochinchinenin B and loureirin B was similar to that of Dragons Blood. All these further proved that the combination of Cochinchinenin A, cochinchinenin B, and loureirin B was the material basis for the analgesic effect of Dragon’s Blood.