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    Danshenol B
    Information
    CAS No. 189308-09-6 Price
    Catalog No.CFN90474Purity>=98%
    Molecular Weight354.43Type of CompoundDiterpenoids
    FormulaC22H26O4Physical DescriptionCryst.
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Danshenol B has aldose reductase(AR) inhibitory activity.
    In vitro:
    Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11.
    Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge.[Pubmed: 9377780]

    METHODS AND RESULTS:
    The constituents of the MeOH extract of Salvia miltiorhiza BUNGE, which showed strong aldose reductase (AR) inhibitory activity, were examined, and two new abietane-type diterpenoids, danshenol A (1) and Danshenol B (2), were isolated together with six known ones: dihydrotanshimme I (3), cryptotanshinone (4), tanshinone I (5), tanshinone IIA (6), (-)-danshexinkun A (7), and sugiol (8). Among them, 4, 5, and 8 were weak AR inhibitors with IC50 from 4.80 to > 10.0 microM, while 1, 2, 3, 6, and 7 were strong inhibitors (IC50 from 0.10 to 1.75 microM).
    CONCLUSIONS:
    Danshenol A (1), the strongest inhibitor, had IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Moreover, from a consideration of IC50, and yield of each compound, it was concluded that tanshinone IIA (6) is the major active constituent of the MeOH extract and danshenol A (I) and (-)danshexinkun A(7) are the minor ones.
    Danshenol B Description
    Source: The roots of Salvia miltiorrhiza
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8214 mL 14.1072 mL 28.2143 mL 56.4286 mL 70.5358 mL
    5 mM 0.5643 mL 2.8214 mL 5.6429 mL 11.2857 mL 14.1072 mL
    10 mM 0.2821 mL 1.4107 mL 2.8214 mL 5.6429 mL 7.0536 mL
    50 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.1286 mL 1.4107 mL
    100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.5643 mL 0.7054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.