Deoxycalyciphylline B | CAS:619326-74-8

Deoxycalyciphylline B

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Description:

Deoxycalyciphylline B exhibits hepatic toxicity. Deoxycalyciphylline B and Methyl homosecodaphniphyllate show different inhibitory effects on thephenoloxidase (PO) of Spodoptera exigua (Hbner) and the inhibitor concentrations leading to 50% (IC50) activity lost are estimated to be 2.439 mmol.L-1 for deoxycalyciphyllineB and 0.879mmol.L-1 for methyl homosecodaphniphyllate,respectively.

In vivo:

Molecules. 2012 Aug 13;17(8):9641-51.

Deoxycalyciphylline B, a hepatotoxic alkaloid from Daphniphyllum calycinum.[Pubmed: 22890169]

Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. It was recorded that DC possessed slight toxicity, which was caused by the alkaloids existing in its extract. Unfortunately, to date the toxicity level and toxic constituents are still unclear.
METHODS AND RESULTS:
The present study is designed to illustrate the acute toxicity and induced organ damages of the total alkaloids as well as to determine the toxic constituents. Based on the above studies, not only was the acute toxicity determined but also hepatic toxicity was characterized by increased plasma biomarkers of ALT and AST and liver cell inflammatory infiltrate as well necrosis that was firstly observed. Significantly, Deoxycalyciphylline B exhibited exactly the same hepatic toxicity so it was identified as the main toxic constituent in DC. An obvious dose-effect relationship between the toxic compound and induced hepatic injuries was also observed. Moreover, the Chinese patent drug Fengliao-Changweikang contained low levels of the toxic compound, compared with the total alkaloids.
CONCLUSIONS:
Therefore, this Chinese patent drug could be regarded to be safe in this point of view.

Deoxycalyciphylline B Description

Source:	The herbs of Daphniphyllum calycinum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Scientia Agricultura Sinica, 2009, 42(10):3720-5.

Inhibitory Effects of Two Compounds Extracted from Daphniphyllum calycinum on Phenoloxidase of Spodotera exigua[Reference: WebLink]

The article studies phenoloxidase inhibitors against insect and finds the clues on new target for pest control.
METHODS AND RESULTS:
The effects of Deoxycalyciphylline B and Methyl homosecodaphniphyllate extracted from Daphniphyllum calycinum. on phenoloxidase (PO) of Spodoptera exigua (H-bner) were investigated adopting the microtitrationassay. The results indicated that the two compounds showed different inhibitory effects on the PO and the inhibitor concentrations leading to 50% (IC50) activity lost were estimated to be 2.439 mmol.L-1 for Deoxycalyciphylline B and 0.879 mmol.L-1 for methyl homosecodaphniphyllate,respectively. The two compounds were also found to be reversible competitive inhibitors and the Ki values were determined to be 2.051 mmol.L-1 and 1.269 mmol.L-1,respectively.
CONCLUSIONS:
Two alkaloids have better inhibitory activities on the PO. The two compounds or their analogues can be used as the templates to guide the molecular design of enzyme inhibitors. These are important ways looking for new pest control agents.

Product Name	Deoxycalyciphylline B
Price:
CAS No.:	619326-74-8
Catalog No.:	CFN97061
Molecular Formula:	C₂₂H₃₁NO₂
Molecular Weight:	341.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Daphniphyllum calycinum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Insecticides Compound Library Hepatotoxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9283 mL	14.6413 mL	29.2826 mL	58.5652 mL	73.2064 mL
5 mM	0.5857 mL	2.9283 mL	5.8565 mL	11.713 mL	14.6413 mL
10 mM	0.2928 mL	1.4641 mL	2.9283 mL	5.8565 mL	7.3206 mL
50 mM	0.0586 mL	0.2928 mL	0.5857 mL	1.1713 mL	1.4641 mL
100 mM	0.0293 mL	0.1464 mL	0.2928 mL	0.5857 mL	0.7321 mL

CFN96959	14-Norpseurotin A	1031727-34-0	417.41	C₂₁H₂₃NO₈
CFN96943	Pseurotin A	58523-30-1	431.44	C₂₂H₂₅NO₈
CFN96607	Triacetylpseurotin A	77353-57-2	557.55	C₂₈H₃₁NO₁₁
CFN96970	FD-838	110341-78-1	411.41	C₂₂H₂₁NO₇
CFN89053	Bisdethiobis(methylthio)gliotoxin	74149-38-5	356.45	C₁₅H₂₀N₂O₄S₂
CFN97061	Deoxycalyciphylline B	619326-74-8	341.5	C₂₂H₃₁NO₂
CFN97062	Deoxyisocalyciphylline B	619326-75-9	341.5	C₂₂H₃₁NO₂