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    Epimedin B1
    Epimedin B1
    Information
    CAS No. 133137-58-3 Price $268 / 5mg
    Catalog No.CFN95017Purity>=98%
    Molecular Weight808.8Type of CompoundFlavonoids
    FormulaC38H48O19Physical DescriptionYellow Powder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade Federal de Goias (U... (Brazil)
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    Biological Activity
    Description: Reference standards.
    In vitro:
    Molecules, 2014, 19(1):686-698.
    Study on the Mechanism of Intestinal Absorption of Epimedins A, B and C in the Caco-2 Cell Model.[Reference: WebLink]
    Epimedium spp. is commonly used in Traditional Chinese Medicine. Epimedin A, Epimedin B(Epimedin B1 ), and Epimedin C are three major bioactive flavonoids found in Epimedium spp. that share similar chemical structures.
    METHODS AND RESULTS:
    In this study, the intestinal absorption mechanism of these three compounds was investigated using the Caco-2 cell monolayer model in both the apical-to-basolateral (A-B) and the basolateral-to-apical (B-A) direction. The absorption permeability (PAB) of epimedin A, epimedin B0, and epimedin C were extremely low and increased as the concentration of the epimedins increased from 5 to 20 μM, but, at 40 μM, the PAB values were reduced. Meanwhile, the amount of transported compounds increased in a time-dependent manner. The PAB of epimedins A and C were significantly increased and efflux ratios decreased in the presence of verapamil (an inhibitor of P-glycoprotein) and dipyridamole (an inhibitor of breast cancer resistance protein) while, in the presence of MK571 (an inhibitor of multidrug resistance proteins), the absorption of epimedins A and C did not change significantly, indicating that P-gp and BCRP might be involved in the transport of epimedins A and C. The PAB of epimedin B significantly increased while its secretory permeability (PBA) significantly decreased in the presence of dipyridamole, indicating that BCRP might be involved in the transport of epimedin B. No obvious changes in the transport of epimedin B were observed in the presence of verapamil and MK571.
    CONCLUSIONS:
    In summary, our results clearly demonstrate, for the first time, that poor bioavailability of these three prenylated flavonoids is the result of poor intrinsic permeability and efflux by apical efflux transporters.
    Epimedin B1 Description
    Source: The herbs of Epimedium sagittatum
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2364 mL 6.182 mL 12.364 mL 24.728 mL 30.91 mL
    5 mM 0.2473 mL 1.2364 mL 2.4728 mL 4.9456 mL 6.182 mL
    10 mM 0.1236 mL 0.6182 mL 1.2364 mL 2.4728 mL 3.091 mL
    50 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    100 mM 0.0124 mL 0.0618 mL 0.1236 mL 0.2473 mL 0.3091 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.