ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $428.8 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Appl Microbiol Biotechnol....2016...J Pharm Biomed Anal.2016, 129:50-59J Ethnopharmacol.2016, 192:370-381Jour. of Stored Pro & Postharvest...2016...Vojnosanit Pregl2016, 75(00):391-391Oncotarget.2016, 8(51):88386-88400University of Central Lancashire...2017...J Agric Food Chem....2017...
Plant J.2017, 90(3):535-546J Sci Food Agric.2017, 97(5):1656-1662Food Quality and Safety2018, 2:213-219Evid Based Complement Alternat Me...2018...Chem Biol Interact.2018, 283:59-74Toxicol In Vitro.2018, 52:94-105Sci Rep.2018, 8:9267Front Microbiol.2019, 10:2806
ACS Chem Biol.2019, 14(5):873-881Chemistry of Plant Materials....2019...Journal of Food Hygiene and Safet...2019...Academic J of Second Military Med...2019...J Food Biochem.2019, 43(9):e12970New Journal of Chemistry...2019...Environ Toxicol Pharmacol....2019...
Our products had been exported to the following research institutions and universities, And still growing.
Utrecht University (Netherlands)Sri Ramachandra University (India)CSIRO - Agriculture Flagship (Australia)VIB Department of Plant Systems... (Belgium)
Univerzita Karlova v Praze (Czech Republic)Universidade de Franca (Brazil)Institute of Bioorganic Chemist... (Poland)University of Parma (Italy)
Universiti Putra Malaysia(UPM) (Malaysia)Monash University (Australia)Uniwersytet Medyczny w ?odzi (Poland)
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Flavonoids Compound Library
|| Reference standards.|
| Molecules, 2014, 19(1):686-698. |
|Study on the Mechanism of Intestinal Absorption of Epimedins A, B and C in the Caco-2 Cell Model.[Reference: WebLink]|
|Epimedium spp. is commonly used in Traditional Chinese Medicine. Epimedin A, Epimedin B(Epimedin B1 ), and Epimedin C are three major bioactive flavonoids found in Epimedium spp. that share similar chemical structures. |
METHODS AND RESULTS:
In this study, the intestinal absorption mechanism of these three compounds was investigated using the Caco-2 cell monolayer model in both the apical-to-basolateral (A-B) and the basolateral-to-apical (B-A) direction. The absorption permeability (PAB) of epimedin A, epimedin B0, and epimedin C were extremely low and increased as the concentration of the epimedins increased from 5 to 20 μM, but, at 40 μM, the PAB values were reduced. Meanwhile, the amount of transported compounds increased in a time-dependent manner. The PAB of epimedins A and C were significantly increased and efflux ratios decreased in the presence of verapamil (an inhibitor of P-glycoprotein) and dipyridamole (an inhibitor of breast cancer resistance protein) while, in the presence of MK571 (an inhibitor of multidrug resistance proteins), the absorption of epimedins A and C did not change significantly, indicating that P-gp and BCRP might be involved in the transport of epimedins A and C. The PAB of epimedin B significantly increased while its secretory permeability (PBA) significantly decreased in the presence of dipyridamole, indicating that BCRP might be involved in the transport of epimedin B. No obvious changes in the transport of epimedin B were observed in the presence of verapamil and MK571.
In summary, our results clearly demonstrate, for the first time, that poor bioavailability of these three prenylated flavonoids is the result of poor intrinsic permeability and efflux by apical efflux transporters.
Epimedin B1 Description
||The herbs of Epimedium sagittatum
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.