ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
ScientificWorldJournal. 2014 Feb 9.Acta Pharmaceutica Sinica B2015 Apr.7.Food Research InternationalJan. 2016Int J Mol Med.2015 Dec 28.Br J Pharmacol.2018 Mar;
Afr. J. Agric. Res. 27 January 2017Evid Based Complement Alternat Med. 2017:1583185Evid Based Complement Alternat Med. 2016 May 24; Int J Mol Sci.2017 Nov 30;Experimental Parasitology2015 March 24.
PLoS One. 2015 May 15.JPCJuly 12, 2017Molecules.2013 Nov 14;18(11):14105-21. JPCMarch 16, 2017
Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Goias (U... (Brazil)Universidade Federal de Pernambu... (Brazil)Deutsches Krebsforschungszentrum (Germany)Univerzita Karlova v Praze (Czech Republic)
University of Maryland School of... (USA)Nicolaus Copernicus Uniwersity (Poland)Mendel University in Brno (Czech Republic)University of Wuerzburg (Germany)
Medical University of Gdansk (Poland)University of Illinois at Chicago (USA)Universiti Kebangsaan Malaysia (Malaysia)
|| Reference standards.|
| Molecules, 2014, 19(1):686-698. |
|Study on the Mechanism of Intestinal Absorption of Epimedins A, B and C in the Caco-2 Cell Model.[Reference: WebLink]|
|Epimedium spp. is commonly used in Traditional Chinese Medicine. Epimedin A, Epimedin B(Epimedin B1 ), and Epimedin C are three major bioactive flavonoids found in Epimedium spp. that share similar chemical structures. |
METHODS AND RESULTS:
In this study, the intestinal absorption mechanism of these three compounds was investigated using the Caco-2 cell monolayer model in both the apical-to-basolateral (A-B) and the basolateral-to-apical (B-A) direction. The absorption permeability (PAB) of epimedin A, epimedin B0, and epimedin C were extremely low and increased as the concentration of the epimedins increased from 5 to 20 μM, but, at 40 μM, the PAB values were reduced. Meanwhile, the amount of transported compounds increased in a time-dependent manner. The PAB of epimedins A and C were significantly increased and efflux ratios decreased in the presence of verapamil (an inhibitor of P-glycoprotein) and dipyridamole (an inhibitor of breast cancer resistance protein) while, in the presence of MK571 (an inhibitor of multidrug resistance proteins), the absorption of epimedins A and C did not change significantly, indicating that P-gp and BCRP might be involved in the transport of epimedins A and C. The PAB of epimedin B significantly increased while its secretory permeability (PBA) significantly decreased in the presence of dipyridamole, indicating that BCRP might be involved in the transport of epimedin B. No obvious changes in the transport of epimedin B were observed in the presence of verapamil and MK571.
In summary, our results clearly demonstrate, for the first time, that poor bioavailability of these three prenylated flavonoids is the result of poor intrinsic permeability and efflux by apical efflux transporters.
Epimedin B1 Description
||The herbs of Epimedium sagittatum
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.