Ermanin | CAS:20869-95-8 | Manufacturer ChemFaces

Ermanin

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Description:

Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent activity at 40 ppm against Dione juno larvae.

Targets:

NO | PGE | NOS | COX | HIV | Antifection

In vitro:

Planta Med. 2010 May;76(7):721-5.

Anti-HIV-1 diterpenoids from leaves and twigs of Polyalthia sclerophylla.[Pubmed: 20013639]

METHODS AND RESULTS:
Bioassay-guided fractionation and purification of the anti-HIV-1-active MeOH extract from the leaves and twigs of Polyalthia sclerophylla led to the isolation of two new compounds, ENT-kaur-sclerodimer ( 1) and cyclotucanol 3-palmitate ( 2), along with the known ENT-kaur-16-en-19-oic acid ( 3), 15 beta-hydroxy- ENT-kaur-16-en-19-oic acid ( 4), 15 beta-acetoxy- ENT-kaur-16-en-19-oic acid ( 5), 15-oxo- ENT-kaur-16-en-19-oic acid ( 6), 16 alpha,17-dihydroxy- ENT-kauran-19-oic acid ( 7), 16 alpha-hydroxy- ENT-kauran-19-oic acid (xylopic acid) ( 8), a pseudodimer (15 alpha-hydroxy- ENT-kaur-16-en-19-oic acid/17-hydroxy- ENT-kaur-15-en-19-oic acid) ( 9), Ermanin, nicotiflorin, and allantoin.
CONCLUSIONS:
Among these isolates, compound 3 was the most active in both anti-syncytium (EC (50) 13.7 microg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC (50) 34.1 microg/mL) assays.

Phytochemistry, 1991, 30(1):153-5.

Ermanin: An insect deterrent flavonoid from Passiflora foetida resin.[Reference: WebLink]

METHODS AND RESULTS:
Ten flavonoids were isolated from Passiflora foetida L. resin. One of them, Ermanin, has a high deterrent activity at 40 ppm against Dione juno larvae.

Ermanin Description

Source:	The herbs of Tanacetum parthenium.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Int Immunopharmacol. 2006 Nov;6(11):1723-8.

Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum.[Pubmed: 16979127]

Plant flavonoids show anti-inflammatory activity both in vitro and in vivo. Some flavonoids have been reported previously to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
METHODS AND RESULTS:
The present study focuses on the effect of various naturally occurring flavonoids (santin, Ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) on modulation of lipopolysaccharide (LPS)-induced iNOS and COX-2 expression in RAW 264.7 cells. Western blotting showed that all flavonoids suppressed the induction of both iNOS and COX-2. Ermanin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol were the most potent inhibitors.
CONCLUSIONS:
This study suggests that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects, and that they may be potential agents for use in the treatment of inflammatory diseases.

Product Name	Ermanin
Price:	$388 / 10mg
CAS No.:	20869-95-8
Catalog No.:	CFN98050
Molecular Formula:	C₁₇H₁₄O₆
Molecular Weight:	314.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Tanacetum parthenium.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insecticides Compound Library Flavonoids Compound Library PGE Inhibitor Library NOS Inhibitor Library NO Inhibitor Library HIV Inhibitor Library COX Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1817 mL	15.9084 mL	31.8167 mL	63.6335 mL	79.5418 mL
5 mM	0.6363 mL	3.1817 mL	6.3633 mL	12.7267 mL	15.9084 mL
10 mM	0.3182 mL	1.5908 mL	3.1817 mL	6.3633 mL	7.9542 mL
50 mM	0.0636 mL	0.3182 mL	0.6363 mL	1.2727 mL	1.5908 mL
100 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.6363 mL	0.7954 mL

CFN92054	Ganoderic acid C2	103773-62-2	518.7	C₃₀H₄₆O₇
CFN97336	Wilforlide A acetate	84104-80-3	496.7	C₃₂H₄₈O₄
CFN98447	Gardneramine	34274-91-4	412.5	C₂₃H₂₈N₂O₅
CFN70480	Eugenol benzoate	531-26-0	268.3	C₁₇H₁₆O₃