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    Harringtonine
    Harringtonine
    Information
    CAS No. 26833-85-2 Price $100 / 20mg
    Catalog No.CFN90891Purity>=98%
    Molecular Weight531.6Type of CompoundAlkaloids
    FormulaC28H37NO9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Harringtonine Description
    Source: The branch of Cephalotaxus fortunei Hook.f.
    Biological Activity or Inhibitors: 1. Harringtonine , an anticancer drug with high chemotherapeutic efficiency to human chronic granulocytic/myelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scope/range of dosage by investigators from our lab and others.
    2. Harringtonine exerts its antiviral effects by inhibiting Chikungunya virus (CHIKV) viral protein synthesis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8811 mL 9.4056 mL 18.8111 mL 37.6223 mL 47.0278 mL
    5 mM 0.3762 mL 1.8811 mL 3.7622 mL 7.5245 mL 9.4056 mL
    10 mM 0.1881 mL 0.9406 mL 1.8811 mL 3.7622 mL 4.7028 mL
    50 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.7524 mL 0.9406 mL
    100 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.3762 mL 0.4703 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Harringtonine References Information
    Citation [1]

    Cancer Lett. 1998 May 15;127(1-2):113-21.

    Intracellular calcium distribution in apoptosis of HL-60 cells induced by harringtonine: intranuclear accumulation and regionalization.[Pubmed: 9619866]
    Harringtonine (HT), an anticancer drug with high chemotherapeutic efficiency to human chronic granulocytic/myelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scope/range of dosage by investigators from our lab and others. In the present studies, by using video enhancement contrast (VEC) microscopy, we dynamically analyzed changes in intracellular calcium distribution in a single HL-60 cell over the period from the initiation of apoptosis to the obvious appearance of chromatin condensation. The results from this paper demonstrated the striking distinction of intracellular calcium distribution at different time points after treatment with HT. Before treatment in normal HL-60 cells the highest [Ca2+]i accumulation was observed in the peri-nuclear area and the lowest was observed in the nucleus; after treatment with 1 microg/ml HT for 30 min intracellular calcium diffused all over the cell compartments, while intranuclear calcium increased comparatively and significantly.
    Citation [2]

    Antimicrob. Agents Chemother., 2013, 57(1): 155-67.

    Inhibition of Chikungunya Virus Replication by Harringtonine, a Novel Antiviral That Suppresses Viral Protein Expression[Reference: WebLink]
    Chikungunya virus (CHIKV) is a mosquito-transmitted virus that has reemerged as a significant public health threat in the last decade. Harringtonine, a cephalotaxine alkaloid, displayed potent inhibition of CHIKV infection (50% effective concentration [EC50] = 0.24 μM) with minimal cytotoxicity and was selected for elucidation of its antiviral mechanism. Time-of-addition studies, cotreatment assays, and direct transfection of viral genomic RNA indicated that Harringtonine inhibited an early stage of the CHIKV replication cycle which occurred after viral entry into cells. In addition, quantitative reverse transcription-PCR (qRT-PCR) and Western blot analyses indicated that Harringtonine affects CHIKV RNA production as well as viral protein expression. Treatment of Harringtonine against Sindbis virus, a related alphavirus, suggested that Harringtonine could inhibit other alphaviruses. This study suggests for the first time that Harringtonine exerts its antiviral effects by inhibiting CHIKV viral protein synthesis.