Natural Products
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| Source: | The herbs of Heliotropium indicum. |
| Biological Activity or Inhibitors: | 1. Indicine N-oxide is a more active antitumor agent than its free base Indicine. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: | Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com |
| After receiving: | The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3405 mL | 16.7023 mL | 33.4046 mL | 66.8092 mL | 83.5115 mL |
| 5 mM | 0.6681 mL | 3.3405 mL | 6.6809 mL | 13.3618 mL | 16.7023 mL |
| 10 mM | 0.334 mL | 1.6702 mL | 3.3405 mL | 6.6809 mL | 8.3511 mL |
| 50 mM | 0.0668 mL | 0.334 mL | 0.6681 mL | 1.3362 mL | 1.6702 mL |
| 100 mM | 0.0334 mL | 0.167 mL | 0.334 mL | 0.6681 mL | 0.8351 mL |
| Citation [1] Anim Genet. 2012 Dec;43(6):785-9. | Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle.[Pubmed: 22497494] |
| This relatively large quantitative trait locus effect appears to be a result of the variation in Indicine and taurine-Indicine composite cattle. However, the only DNA variant found in Brahman cattle that altered the predicted amino acid sequence of XKR4 was not associated with rump fat thickness. This suggests that causative mutations lie outside the coding sequence of this gene. | |
| Citation [2] Theriogenology. 2015 Sep 1;84(4):624-33. | Comparative proteomic analysis of Taurine, Indicine, and crossbred (Bos taurus × Bos indicus) bull spermatozoa for identification of proteins related to sperm malfunctions and subfertility in crossbred bulls.[Pubmed: 26033646] |
| Subfertility is one of the most common problems observed among Taurine × Indicine crossbred bulls in tropical countries; however, the etiology remain unknown in most of the cases. In present study, we compared the proteomic profile of spermatozoa from crossbred bulls (Bos taurus × Bos indicus) against their purebred parent lines (Holstein Friesian [Taurine] and Tharparkar [Indicine]) to find out alteration in expressions of proteins, if any. | |
| Citation [3] Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):559-69. | Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity.[Pubmed: 451340] |
| Indicine N-oxide is an exception in that it is a more active antitumor agent than its free base Indicine. Studies of the antitumor activity and metabolism of Indicine N-oxide, and the closely related compound, heliotrine N-oxide, given orally and intraperitoneally to mice bearing P-388 leukemia, suggest that conversion of Indicine N-oxide to Indicine is not essential for its antitumor activity. |
