Indicine | CAS:480-82-0 | Manufacturer ChemFaces

Indicine

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Description:

Indicine N-oxide is a more active antitumor agent than its free base Indicine.

In vivo:

Anim Genet. 2012 Dec;43(6):785-9.

Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle.[Pubmed: 22497494]

Variation in the XK, Kell blood group complex subunit-related family, member 4 (XKR4) gene on BTA14 was associated with rump fat thickness in a recent genome-wide association study. This region is also of interest because it is known to show evidence of a signature of population genetic selection.
METHODS AND RESULTS:
In this study, additional variation in this gene was genotyped in a sample of a total of 1283 animals of the Belmont Red (BEL) and Santa Gertrudis (SGT) breeds. The SNP rs41724387 was significantly (P < 0.001) associated with rump fat thickness and explained 5.9% of the genetic variance for the trait in this sample. Using the 4466 genotypes for the SNP rs42646708 from several data sets to estimate effects in seven breeds, this relatively large quantitative trait locus effect appears to be a result of the variation in Indicine and taurine-Indicine composite cattle. However, the only DNA variant found in Brahman cattle that altered the predicted amino acid sequence of XKR4 was not associated with rump fat thickness.
CONCLUSIONS:
This suggests that causative mutations lie outside the coding sequence of this gene.

Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):559-69.

Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity.[Pubmed: 451340]

Several pyrrolizidine alkaloids have been demonstrated to have antitumor activity in experimental tumor systems.
METHODS AND RESULTS:
In general the free base form of the alkaloid exhibits greater biological activity than the corresponding N-oxide and the N-oxide must be metabolized to the base for the subsequent formation of alkylating intermediates. Indicine N-oxide is an exception in that it is a more active antitumor agent than its free base Indicine.
CONCLUSIONS:
Studies of the antitumor activity and metabolism of Indicine N-oxide, and the closely related compound, heliotrine N-oxide, given orally and intraperitoneally to mice bearing P-388 leukemia, suggest that conversion of Indicine N-oxide to Indicine is not essential for its antitumor activity.

Indicine Description

Source:	The herbs of Heliotropium indicum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Theriogenology. 2015 Sep 1;84(4):624-33.

Comparative proteomic analysis of Taurine, Indicine, and crossbred (Bos taurus × Bos indicus) bull spermatozoa for identification of proteins related to sperm malfunctions and subfertility in crossbred bulls.[Pubmed: 26033646]

Subfertility is one of the most common problems observed among Taurine × Indicine crossbred bulls in tropical countries; however, the etiology remain unknown in most of the cases.
METHODS AND RESULTS:
In present study, we compared the proteomic profile of spermatozoa from crossbred bulls (Bos taurus × Bos indicus) against their purebred parent lines (Holstein Friesian [Taurine] and Tharparkar [Indicine]) to find out alteration in expressions of proteins, if any. The proteomic profiles of freshly ejaculated spermatozoa from these breeds were compared by two-dimensional difference gel electrophoresis, and differentially expressed proteins were identified through mass spectrometry. It was observed that compared to Holstein Friesian, nine proteins were underexpressed and eight proteins were overexpressed (P < 0.05) in the spermatozoa of crossbred bulls. Similarly, four proteins were overexpressed and four proteins were underexpressed (P < 0.05) in the spermatozoa of crossbred bulls compared to Tharparkar bulls. In concurrent three breed comparison, 14 proteins were found to be differentially expressed (P < 0.05) between these breeds.
CONCLUSIONS:
From the findings of the study, it is apparent that the expression levels of several functionally significant proteins are either upregulated or downregulated in spermatozoa of crossbred bulls, which might be related to high incidence of subfertility in these bulls.

Product Name	Indicine
Price:
CAS No.:	480-82-0
Catalog No.:	CFN00283
Molecular Formula:	C₁₅H₂₅NO₅
Molecular Weight:	299.36 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The herbs of Heliotropium indicum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3405 mL	16.7023 mL	33.4046 mL	66.8092 mL	83.5115 mL
5 mM	0.6681 mL	3.3405 mL	6.6809 mL	13.3618 mL	16.7023 mL
10 mM	0.334 mL	1.6702 mL	3.3405 mL	6.6809 mL	8.3511 mL
50 mM	0.0668 mL	0.334 mL	0.6681 mL	1.3362 mL	1.6702 mL
100 mM	0.0334 mL	0.167 mL	0.334 mL	0.6681 mL	0.8351 mL

CFN00518	7-O-Acetylintermedine N-oxide	685132-59-6	357.4	C₁₇H₂₇NO₇
CFN00287	Lycopsamine	10285-07-1	299.37	C₁₅H₂₅NO₅
CFN00288	7-Acetyllycopsamine	73544-48-6	341.40	C₁₇H₂₇NO₆
CFN00277	Petasinoside	70474-34-9	531.60	C₂₈H₃₇NO₉
CFN00278	Thesinine	488-02-8	287.36	C₁₇H₂₁NO₃
CFN00282	Ehretinine	76231-29-3	275.35	C₁₆H₂₁NO₃
CFN00283	Indicine	480-82-0	299.36	C₁₅H₂₅NO₅
CFN00284	Indicine N-oxide	41708-76-3	315.37	C₁₅H₂₅NO₆
CFN00285	Intermedine	10285-06-0	299.36	C₁₅H₂₅NO₅
CFN00459	Intermedine N-oxide	95462-14-9	315.4	C₁₅H₂₅NO₆