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More articles cited ChemFaces products.
J. of Food Composition & Analysis2017Front Pharmacol. 2016 Nov 30Cytotechnology. 2017 Apr 3.Evidence-Based Comp. & Alter. Med.Dec. 27, 2015Viruses. 2017 Oct 3;9(10).
Evid Based Complement Alternat Med. 2016 Jun 13.Int. Conference on Med. Sci. and Bio.2017;Molecules. 2017 Feb 8;Nat Prod Sci.2016 Jun;22(2)Sci Rep. 2017 Jun 12;
J Pharm Biomed Anal. 2016 Jun 25;129:50-59. Arch Toxicol. 2017 Mar 20. Molecules. 2016 Oct 20BMC Complement Altern Med.2017 Aug 3;
Our products had been exported to the following research institutions and universities, And still growing.
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||Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway, loureirin B can suppress tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents in a dose-dependent way.|
||TGF-β/Smad | MMP(e.g.TIMP) | GLUT | Calcium Channel | PAI-1 | ERK | JNK|
|Exp Dermatol. 2015 May;24(5):355-60. |
|Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway.[Pubmed: 25683490]|
|The ethanolic extract of Resina Draconis (RDEE) has been reported beneficial to normal wound healing yielding more regularly arranged collagen fibres. Loureirin B, a major component in RDEE, has been supposed to be effective on the prevention and treatment of pathological scars.
METHODS AND RESULTS:
To investigate the therapeutic effects of Loureirin B on hypertrophic scar (HS), fibroblasts from human HS and normal skin (NS) were isolated. Results showed that Loureirin B dose-dependently downregulated both mRNA and protein levels of type I collagen (ColI), type III collagen (ColIII) and α-smooth muscle actin (α-SMA) in HS fibroblasts. Loureirin B also suppressed fibroblast proliferative activity and redistributed cell cycle, but did not affect cell apoptosis. In vivo rabbit ear scar model, Loureirin B significantly improved the arrangement and deposition of collagen fibres, decreased protein levels of ColI, ColIII and α-SMA and suppressed myofibroblast differentiation and scar proliferative activity. In NS fibroblasts, Loureirin B effectively inhibited TGF-β1-induced upregulation of ColI, ColIII and α-SMA levels, myofibroblast differentiation and the activation of Smad2 and Smad3. Loureirin B also affected mRNA levels of major MMPs and TIMPs in TGF-β1-stimulated fibroblasts.
Taken together, this study demonstrates that Loureirin B could downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved. These findings suggest that Loureirin B is a potential therapeutic compound for HS treatment.
|Sci China C Life Sci. 2004 Aug;47(4):340-8. |
|Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons.[Pubmed: 15493475]|
|Using whole-cell patch clamp technique on the membrane of freshly isolated dorsal root ganglion (DRG) neurons, the effects of dragon's blood resin and its important component Loureirin B on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents were observed.
METHODS AND RESULTS:
The results show that both blood resin and Loureirin B could suppress TTX-S voltage-gated sodium currents in a dose-dependent way. The peak current amplitudes and the steady-state activation and inactivation curves are also made to shift by 0.05% blood resin and 0.2 mmol/L Loureirin B.
These results demonstrate that the effects of blood resin on TTX-S sodium current may contribute to Loureirin B in blood resin. Perhaps the analgesic effect of blood resin is caused partly by Loureirin B directly interfering with the nociceptive transmission of primary sensory neurons.
Loureirin B Description
||The herbs of Dracaena cochinchinensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Cell Biosci. 2014 Dec 12;4:78. |
|Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells.[Pubmed: 25937895]|
|Sanguis draxonis (SD), also known as "Dragon's Blood", is a traditional herb medicine that has been used to treat a variety of complications with unknown mechanisms. Recent studies show that SD displays immunosuppressive activities and improves symptoms of type I diabetes in animal models. However, the mechanisms underlying SD's immunosuppressive actions are not completely understood. The voltage-gated Kv1.3 channel plays a critical role in the pathogenesis of autoimmune diseases by regulating the functions of both T cells and B cells.
METHODS AND RESULTS:
Here we investigated the effect of SD and one of its active components Loureirin B (LrB) on Kv1.3. Both SD and LrB inhibited Kv1.3-mediated currents, produced a membrane depolarization, and reduced Ca(2+) influx in Jurkat T cells. In addition, application of LrB inhibited phytohemagglutinin (PHA)-induced IL-2 release from activated Jurkat T cells. Furthermore, point mutations in the selective filter region significantly reduced the inhibitory effect of LrB on Kv1.3.
The results of these experiments provide evidence that LrB is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and LrB might be the cellular and molecular basis of SD-mediated immunosuppression.
|Shandong Medical Journal, 2012, 52(13):7-9. |
|Effect of loureirin B on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro.[Reference: WebLink]|
|To investigate the effects of Loureirin B on proliferation and extracellular matrix secretion of rat hepatic stellate cells in vitro.
METHODS AND RESULTS:
HSC-T6 was cultured in 96-well plates for 24 hours.Then they were incubated with different concentration of Loureirin B for 48 hours.MTT was used for assaying proliferation of HSC.Inhibition rate was calculated.Hyaluronic acid,laminin and collagen type Ⅳ were measured by radioimmunoassay. Addition of Loureirin B into culture medium significantly inhibited HSC proliferation,and the higher concentration of the Loureirin B were,the stronger inhibition rate of the HSC had.It also inhibited hyaluronic acid,laminin and collagen type Ⅳ secretion in different degree.
Loureirin B significantly inhibits HSC proliferation and extracellular matrix secretion.
|Chinese Journal of Experimental Traditional Medical, 2013, 19(23):254-7. |
|Protective Effects of Loureirin B on Dysfunction of Pacreatic Islet β Cell Induced by Palmitate.[Reference: WebLink]|
|To study the protective effects and mechanism of Loureirin B on the dysfunctiion of pancreatic islet β cell induced by palmitic acid.
METHODS AND RESULTS:
NIT-1 cells were cultured in medium added palmitic acid,and treated with Loureirin B.Cell apoptosis ratio and content of reactive oxygen species(ROS) were detected by flow cytometry,the expressions of glucose tnansport receptor-2(GLUT2) was examined by semiquantitate reverse transcript PCR.Compared with palmitic acid treated group,survival rate of NIT-1 with Loureirin B(20,10 μmol·L- 1) was increased significantly(P0.05).Loureirin B(20,10,5 μmol·L- 1)scavenged excessive ROS and lowered its concentration significantly(P0.05).Loureirin B(20 μmol·L- 1) was increased the expressions of GLUT2(P0.05),and Loureirin B(20,10,5 μmol·L- 1) was effective on reducing apoptosis ratio induced by palmitic acid(P0.05).
Loureirin B can increase the survival rate of NIT-1 cultured in the medium added palmitic acid,scavenge excessive ROS induced by palmitic acid,decrease the cell apoptosis ratio and elevate the expressions of GLUT2.This indicates Loureirin B may accomplish its islet cell protection effects by reducing ROS within cell and reversing glucose metabolism disorder rand other effects induced by forkhead box protein-1(FOXO1) activated by oxidative stress.