Parsonsine | CAS:72213-98-0 | Manufacturer ChemFaces

Parsonsine

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Parsonsine Description

Source:	The leaves of Parsonsia laevigata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Insect Biochem Mol Biol. 2003 May;33(5):515-23.

Biochemical processing of plant acquired pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi.[Pubmed: 12706631]

Leaf beetles of the genus Platyphora, feeding on plant species containing pyrrolizidine alkaloids of the lycopsamine type, not only sequester these alkaloids and concentrate them in their exocrine defensive secretions, but also specifically process the plant acquired alkaloids.
METHODS AND RESULTS:
Using P. boucardi as subject, three mechanisms were studied: (i). utilization of host plant alkaloids that are not sequestered per se; (ii). elucidation of the mechanism of the already documented C-7 epimerization of heliotridine O(9)-monoesters; (iii). the specificity of insect catalyzed necine base esterification. P. boucardi does not sequester the triester Parsonsine, the principal alkaloid of its host plant Prestonia portobellensis (Apocynaceae). Beetles fed with a purified mixture of nor-derivatives of Parsonsine, obtained from Parsonsia laevigata, did not sequester the triesters but transformed them by partial degradation into monoesters that are accumulated in the defensive secretions. The mechanism of the previously described transformation of rinderine into intermedine by C-7 epimerization was elucidated by feeding C-7 deuterated heliotrine (3'-methylrinderine). The transformation of heliotrine into epiheliotrine (3'-methylintermedine) catalyzed by P. boucardi is accompanied by complete loss of deuterium, indicating the same mechanism of an oxidation-reduction process via a ketone intermediate as recently demonstrated in a pyrrolizidine alkaloid sequestering lepidopteran.
CONCLUSIONS:
P. boucardi is able to form ester alkaloids from five different necine bases fed as radioactively labeled substrates. However, besides C-7 epimerization the beetles are not able to convert simple necine bases into retronecine. The functional importance of the various alkaloid transformations is discussed in comparison to striking parallels of analogous reactions known from pyrrolizidine alkaloid sequestering Lepidoptera.

Product Name	Parsonsine
Price:
CAS No.:	72213-98-0
Catalog No.:	CFN00399
Molecular Formula:	C₂₂H₃₃NO₈
Molecular Weight:	439.50 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The leaves of Parsonsia laevigata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2753 mL	11.3766 mL	22.7531 mL	45.5063 mL	56.8828 mL
5 mM	0.4551 mL	2.2753 mL	4.5506 mL	9.1013 mL	11.3766 mL
10 mM	0.2275 mL	1.1377 mL	2.2753 mL	4.5506 mL	5.6883 mL
50 mM	0.0455 mL	0.2275 mL	0.4551 mL	0.9101 mL	1.1377 mL
100 mM	0.0228 mL	0.1138 mL	0.2275 mL	0.4551 mL	0.5688 mL

CFN00461	Jacobine N-oxide	38710-25-7	367.4	C₁₈H₂₅NO₇
CFN00380	Madurensine	26126-78-3	351.40	C₁₈H₂₅NO₆
CFN00382	Spiranine	77156-23-1	469.53	C₂₃H₃₅NO₉
CFN00385	Monocrotaline N-oxide	35337-98-5	341.36	C₁₆H₂₃NO₇
CFN00386	Spectabiline	520-55-8	367.40	C₁₈H₂₅NO₇
CFN00399	Parsonsine	72213-98-0	439.50	C₂₂H₃₃NO₈
CFN00400	Spiraline	77156-25-3	455.50	C₂₂H₃₃NO₉
CFN00416	Seneciocannabine	81855-31-4	365.38	C₁₈H₂₃NO₇
CFN00431	Swazine	38763-74-5	349.38	C₁₈H₂₃NO₆
CFN00437	Antibiotic PF 1018	131256-42-3	433.59	C₂₈H₃₅NO₃