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    Periplocoside M
    Periplocoside M
    Information
    CAS No. 116782-73-1 Price
    Catalog No.CFN93161Purity>=98%
    Molecular Weight604.78Type of CompoundSteroids
    FormulaC34H52O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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  • Mahatma Gandhi University (India)
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  • Leibniz Institute of Plant Bioch... (Germany)
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    Periplocoside M Description
    Source: The roots of Periploca sepium Bge.
    Biological Activity or Inhibitors: 1. Periplocoside M possesses observably antitumor activity against SMMC-7721( IC 50=12.9 ng/L),Hela( IC 50=8.63 ng/L) and MCF-7( IC 50=18.5 ng/L) cancer cell lines.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6535 mL 8.2675 mL 16.5349 mL 33.0699 mL 41.3373 mL
    5 mM 0.3307 mL 1.6535 mL 3.307 mL 6.614 mL 8.2675 mL
    10 mM 0.1653 mL 0.8267 mL 1.6535 mL 3.307 mL 4.1337 mL
    50 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.6614 mL 0.8267 mL
    100 mM 0.0165 mL 0.0827 mL 0.1653 mL 0.3307 mL 0.4134 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Periplocoside M References Information
    Citation [1]

    Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(15):2286-8.

    A new cardiac glycoside from Periploca forrestii.[Pubmed: 23189735]
    To study the chemical constituents of Periploca forrestii. METHOD: The constituents were separate using such various column chromatographic techniques as silica gel, RP-18 silica gel, MCI and Sephadex LH-20. Their structures were identified by such methods as spectral analysis. RESULT: Ten compounds were isolated and identified as periforgenin A-3-O-beta-digitoxopyranoside (1), beta-sitosterol (2), periforoside I (3), ursolic acid (4), periplogenin (5), periplocin (6), glycoside E (7), Periplocoside M (8) , daucosterol (9), 2alpha, 3alpha, 23-trihydroxy-urs-12-en-28-oic acid (10). CONCLUSION: Compound 1 was a new cardiac glycoside and compound 8 was reported for the first time from this plant.
    Citation [2]

    China Journal of Chinese Medicine, 2014.

    Study on Antitumor Activity and Structure-activity Relationship of C21 Steroids from Periplocae Cortex[Reference: WebLink]
    Objective: To investigate the antitumor activity of five C21 steroids and illuminate the structure-activity relationship. Methods: MTT assay was firstly used to explore the cytotoxic activity against three cancer cell lines in vitro of compound 1- 5 isolated from Periplocae Cortex. Results: Among the five compounds,compound 1 possessed observably antitumor activity against SMMC-7721( IC 50 12. 9 ng·L- 1),Hela( IC 50 8. 63 ng·L- 1) and MCF-7( IC 50 18. 5 ng·L- 1) cancer cell lines. Conclusion: Compound 1( Periplocoside M) possessed observably cytotoxic activity. The SAR of the five compounds indicated that C-3 was an important position for keeping the cytotoxic activity of C21 steroids from Periplocae Cortex.