ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Phytomedicine1 Feb. 2018;Journal of Pharmaceutical Analysis2016 May 5; Free Radic Biol Med.2017 Nov;Food Chemistry.2015 Feb.7.Biomed Chromatogr. 2016 Mar 23.
Braz J Med Biol Res. 2016 Jul 4;49(7).J Ethnopharmacol. 2017 Feb 2;Evid Based Complement Alternat Med. 2018;Scientific Research.2015 Jan 6; 14-23J Ethnopharmacol.2016 Jun 25.
Int J Mol Sci. 2018 Jan 23;Journal of Agricultural Science2015 Sep 15Int J Mol Sci. 2017 May 11;LWT - Food Science and Technology2017 Jan.
Our products had been exported to the following research institutions and universities, And still growing.
Universidade do Porto (Portugal)Siksha O Anusandhan University (India)Universite Libre de Bruxelles (Belgium)Centralised Purchases Unit (CPU)... (India)
Sri Sai Aditya Institute of Phar... (India)Monash University Malaysia (Malaysia)University of Illinois at Chicago (USA)S.N.D.T. Women's University (India)
University of Malaya (Malaysia)Donald Danforth Plant Science Ce... (USA)Research Unit Molecular Epigenet... (Germany)
||Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.|
|Phytother Res. 2013 Aug;27(8):1179-84. |
|Maohuoside A acts in a BMP-dependent manner during osteogenesis.[Pubmed: 23007945]|
|There has been a strong interest in searching for natural therapies for osteoporosis. Epimedium koreanum Nakai is an herb that is commonly used in East Asia to treat osteoporosis, and most studies of its activity have focused on its major ingredient, icariin. |
METHODS AND RESULTS:
In this study, Maohuoside A (MHA), a single compound isolated from the E. koreanum, was found to promote osteogenesis in mouse bone marrow-derived mesenchymal stem cells. We hypothesise that, if Maohuoside A potently induces osteogenic differentiation in a bone morphogenetic protein-dependent manner, it may be used to broaden the sources for cell transplantation and thereby establish more efficient bone regeneration systems. Real-time polymerase chain reaction and western blot were used to detect the expression of SMAD4, a marker of bone formation. Microcomputed tomography and histomorphometric techniques showed that oral treatment with Maohuoside A was followed by an increase in the bone mineral density of the lumbar vertebrae in mice. This result also indicates that Maohuoside A may directly activate osteopontin gene transcription.
In conclusion, Maohuoside A seems to enhance the osteogenesis of bone marrow-derived mesenchymal stem cells at least partly via bone morphogenetic protein signalling.
Maohuoside A Description
||The roots of Epimedium brevicornu Maxim
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Mol Cell Biochem. 2011 Dec;358(1-2):37-44. |
|Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.[Pubmed: 21698346]|
|Osteoporosis is becoming a more prevalent health problem with the aging of the population around the world. Epimedium koreanum Nakai is one of the most used herbs in East Asia for curing osteoporosis, with its major ingredient, icariin, mostly explored by researchers. |
METHODS AND RESULTS:
In this article, Maohuoside A (MHA), a single isolated compound from the herb, was identified to be more potent than icariin in promoting osteogenesis of rat bone marrow-derived mesenchymal stem cells (rMSCs) (increasing by 16.6, 33.3, and 15.8% on D3, D7, and D11, respectively). Alkaline phosphatase (ALP) assay and calcium content measurement were assigned to quantify the promoted osteogenesis and alizarin red S (ARS) staining was conducted to visualize it. Quantitative real-time PCR (Q-PCR) was assayed to evaluate the mRNA expression of marker genes in osteogenesis and master regulators in BMP pathway. Moreover, PD98059 (PD) and SB203580 (SB), inhibitor of ERK1/2 and p38 MAPK pathway, were administered to assess the involvement of MAPK pathway in the promotion process.
In conclusion, MHA pronouncedly enhanced the osteogenesis of rMSC, plausibly via the BMP and MAPK signaling pathways.