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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Evid Based Complement Alternat Me...2015...Food Research International...2016...Molecules.2016, 21(6)Chem Biol Interact.2016, 258:59-68Biomed Chromatogr.2016, 30(10):1573-81Int J Anal Chem.2017, 2017:1254721J Ethnopharmacol.2017, 209:305-316Phytomedicine.2017, 24:77-86
FEMS Microbiol Lett.2017, 364(11)Front Immunol.2017, 8:1542The Pharmaceutical Society of Jap...2018...Lab Chip.2018, 18(6):971-978Food and Fermentation Industries...2018...Front Pharmacol.2018, 9:236Pharmacognosy Journal...2019...J Adv Res.2019, 17:85-94
Molecules.2019, 24(7):E1290Academic J of Second Military Med...2019...New Journal of Chemistry...2019...J of Ana. Chem.2019, 74(11):1113-1121Psychopharmacology (Berl).2020, 10.1007Int J Pharmacol2020, 16:1-9Antioxidants (Basel).2020, 9(2):E120
Our products had been exported to the following research institutions and universities, And still growing.
Charles Sturt University (Denmark)Universitas Airlangga (Indonesia)Medical University of Gdansk (Poland)Imperial College London (United Kingdom)
Sanford Burnham Medical Researc... (USA)Ateneo de Manila University (Philippines)Deutsches Krebsforschungszentrum (Germany)Kyoto University (Japan)
University of South Australia (Australia)Instituto Politécnico de Bragan?a (Portugal)Cornell University (USA)
Related Screening Libraries
||Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.|
|Phytother Res. 2013 Aug;27(8):1179-84. |
|Maohuoside A acts in a BMP-dependent manner during osteogenesis.[Pubmed: 23007945]|
|There has been a strong interest in searching for natural therapies for osteoporosis. Epimedium koreanum Nakai is an herb that is commonly used in East Asia to treat osteoporosis, and most studies of its activity have focused on its major ingredient, icariin. |
METHODS AND RESULTS:
In this study, Maohuoside A (MHA), a single compound isolated from the E. koreanum, was found to promote osteogenesis in mouse bone marrow-derived mesenchymal stem cells. We hypothesise that, if Maohuoside A potently induces osteogenic differentiation in a bone morphogenetic protein-dependent manner, it may be used to broaden the sources for cell transplantation and thereby establish more efficient bone regeneration systems. Real-time polymerase chain reaction and western blot were used to detect the expression of SMAD4, a marker of bone formation. Microcomputed tomography and histomorphometric techniques showed that oral treatment with Maohuoside A was followed by an increase in the bone mineral density of the lumbar vertebrae in mice. This result also indicates that Maohuoside A may directly activate osteopontin gene transcription.
In conclusion, Maohuoside A seems to enhance the osteogenesis of bone marrow-derived mesenchymal stem cells at least partly via bone morphogenetic protein signalling.
Maohuoside A Description
||The roots of Epimedium brevicornu Maxim
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Mol Cell Biochem. 2011 Dec;358(1-2):37-44. |
|Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.[Pubmed: 21698346]|
|Osteoporosis is becoming a more prevalent health problem with the aging of the population around the world. Epimedium koreanum Nakai is one of the most used herbs in East Asia for curing osteoporosis, with its major ingredient, icariin, mostly explored by researchers. |
METHODS AND RESULTS:
In this article, Maohuoside A (MHA), a single isolated compound from the herb, was identified to be more potent than icariin in promoting osteogenesis of rat bone marrow-derived mesenchymal stem cells (rMSCs) (increasing by 16.6, 33.3, and 15.8% on D3, D7, and D11, respectively). Alkaline phosphatase (ALP) assay and calcium content measurement were assigned to quantify the promoted osteogenesis and alizarin red S (ARS) staining was conducted to visualize it. Quantitative real-time PCR (Q-PCR) was assayed to evaluate the mRNA expression of marker genes in osteogenesis and master regulators in BMP pathway. Moreover, PD98059 (PD) and SB203580 (SB), inhibitor of ERK1/2 and p38 MAPK pathway, were administered to assess the involvement of MAPK pathway in the promotion process.
In conclusion, MHA pronouncedly enhanced the osteogenesis of rMSC, plausibly via the BMP and MAPK signaling pathways.