Strictosidinic acid | CAS:150148-81-5 | Manufacturer ChemFaces

Strictosidinic acid

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Strictosidinic acid has an antiradical action against DPPH, it has a promising effect in the central nervous system.

In vitro:

Pharmaceutical Biology, 2008, 41(8):592-597.

Anti-allergic and Antioxidative Activities of Some Compounds from Thai Medicinal Plants.[Reference: WebLink]

METHODS AND RESULTS:
In a DPPH radical scavenging assay, Strictosidinic acid and barakol were more potent than the positive control, BHT. The EC50 values of Strictosidinic acid and barakol were 27.68 and 39.62 μM, respectively. Other tested compounds, including lawsone methyl ether, bergenin, homorapanone and lucidin-ω-methyl ether, had weak antioxidative activities or no activity. In a nitrite assay, only lawsone methyl ether reduced nitrite production with an EC50 of 10.27 μM in RAW 264.7 cells.
CONCLUSIONS:
In conclusion, lawsone methyl ether suppresses degranulation in RBL-2H3 cells and reduces nitrite production in RAW 264.7 cells whereas Strictosidinic acid and barakol have an antiradical action against DPPH.

In vivo:

Phytomedicine. 2010 Mar;17(3-4):289-91.

Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae).[Pubmed: 19576739]

METHODS AND RESULTS:
Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%).
CONCLUSIONS:
The results indicate that Strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds.

Strictosidinic acid Description

Source:	The leaves of Psychotria myriantha.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Strictosidinic acid
Price:
CAS No.:	150148-81-5
Catalog No.:	CFN96657
Molecular Formula:	C₂₆H₃₂N₂O₉
Molecular Weight:	516.54 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The leaves of Psychotria myriantha.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Neuroprotection Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.936 mL	9.6798 mL	19.3596 mL	38.7192 mL	48.399 mL
5 mM	0.3872 mL	1.936 mL	3.8719 mL	7.7438 mL	9.6798 mL
10 mM	0.1936 mL	0.968 mL	1.936 mL	3.8719 mL	4.8399 mL
50 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.7744 mL	0.968 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.3872 mL	0.484 mL

CFN98237	Strictosamide	23141-25-5	498.5	C₂₆H₃₀N₂O₈
CFN98238	Vincosamide	23141-27-7	498.5	C₂₆H₃₀N₂O₈
CFN96657	Strictosidinic acid	150148-81-5	516.54	C₂₆H₃₂N₂O₉
CFN92745	3Beta-Isodihydrocadambine 4-oxide	1092371-18-0	562.6	C₂₇H₃₄N₂O₁₁
CFN80224	3alpha-dihydrocadambine	54483-84-0	546.22	C₂₇H₃₄N₂O₁₀
CFN92640	Vallesiachotamine	5523-37-5	350.4	C₂₁H₂₂N₂O₃
CFN92641	Isovallesiachotamine	34384-71-9	350.4	C₂₁H₂₂N₂O₃
CFN96096	(16R)-E-Isositsirikine	6519-27-3	354.5	C₂₁H₂₆N₂O₃
CFN95566	Geissoschizine	439-66-7	368.4	C₂₁H₂₄N₂O₄
CFN89459	Geissoschizine methyl ether	60314-89-8	366.45	C₂₂H₂₆N₂O₃