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    Tsugaric acid A
    Tsugaric acid A
    Information
    CAS No. 174391-64-1 Price
    Catalog No.CFN90990Purity>=98%
    Molecular Weight498.8Type of CompoundTriterpenoids
    FormulaC32H50O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates that tsugaric acid A can protect keratinocytes from photodamage.
    Targets: NO | IFN-γ
    In vitro:
    Phytochemistry. 2008 Jan;69(1):234-9.
    Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae.[Pubmed: 17655889 ]
    The antiinflammatory properties of triterpenoids and steroids from both Ganoderma lucidum and Ganoderma tsugae were studied.
    METHODS AND RESULTS:
    Twelve compounds, including ergosta-7,22-dien-3beta-ol (1), ergosta-7,22-dien-3beta-yl palmitate (2), ergosta-7,22-dien-3-one (3), ergosta-7,22-dien-2beta,3alpha,9alpha-triol (4), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (5), ganoderal A (6), ganoderal B (7), ganoderic aldehyde A (8), Tsugaric acid A (9), 3-oxo-5alpha-lanosta-8,24-dien-21-oic acid (10), 3alpha-acetoxy-5alpha-lanosta-8,24-dien-21-oic acid ester beta-d-glucoside (11), and tsugaric acid B (12), were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells, neutrophils, and macrophages.
    CONCLUSIONS:
    Compound 10 showed a significant inhibitory effect on the release of beta-glucuronidase from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB) whereas compound 9 significantly inhibited superoxide anion formation in fMLP/CB-stimulated rat neutrophils. Compound 10 also exhibited a potent inhibitory effect on NO production in lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-stimulated N9 microglial cells. Moreover, compound 9 was also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, which indicated 9 could protect keratinocytes from photodamage.
    Tsugaric acid A Description
    Source: The sclerotium of Poria cocos (Schw.) Wolf
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0048 mL 10.0241 mL 20.0481 mL 40.0962 mL 50.1203 mL
    5 mM 0.401 mL 2.0048 mL 4.0096 mL 8.0192 mL 10.0241 mL
    10 mM 0.2005 mL 1.0024 mL 2.0048 mL 4.0096 mL 5.012 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8019 mL 1.0024 mL
    100 mM 0.02 mL 0.1002 mL 0.2005 mL 0.401 mL 0.5012 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.