Science | Nature | Cell | View More
Natural Products
Vinorelbine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Vinorelbine
Price: $168 / 20mg
CAS No.: 71486-22-1
Catalog No.: CFN90401
Molecular Formula: C45H54N4O8
Molecular Weight: 778.93 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Catharanthus roseus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $44.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Ain Shams University (Egypt)
  • Mahatma Gandhi University (India)
  • Hamdard University (India)
  • The Institute of Cancer Research (United Kingdom)
  • Siksha O Anusandhan University (India)
  • University of Bordeaux (France)
  • Washington State University (USA)
  • Leibniz Institute of Plant Bioc... (Germany)
  • University of South Australia (Australia)
  • Seoul National University of Sc... (Korea)
  • Florida International University (USA)
  • More...
Package
Featured Products
Saikosaponin A

Catalog No: CFN99987
CAS No: 20736-09-8
Price: $80/20mg
Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg
Jujuboside D

Catalog No: CFN98103
CAS No: 194851-84-8
Price: $360/10mg
Crocin I

Catalog No: CFN99927
CAS No: 94238-00-3
Price: $100/20mg
Ophiopogonin D

Catalog No: CFN98156
CAS No: 41753-55-3
Price: $248/20mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
Hotrienol

Catalog No: CFN99583
CAS No: 20053-88-7
Price: $ / mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Vinorelbine is a semi-synthetic Vinca alkaloid which is currently used in treatment of different cancer types mainly advanced breast cancer (ABC) and advanced/metastatic non-small cell lung cancer (NSCLC). Vinorelbine-loaded SSM can be developed as a new, safe, stable, and effective nanomedicine for the treatment of breast and lung cancers.
In vivo:
Lung Cancer. 2015 May;88(2):167-73.
Intravenous or oral administration of vinorelbine in adjuvant chemotherapy with cisplatin and vinorelbine for resected NSCLC.[Pubmed: 25769883 ]
Cisplatin and Vinorelbine given intravenously is a well-established adjuvant chemotherapy regimen after surgery for early-stage NSCLC. Vinorelbine can also be administered orally. However, the efficacy of orally administrated Vinorelbine in adjuvant treatment of NSCLC is unknown. We assessed the overall survival (OS) and disease-free survival (DFS) of patients treated with adjuvant i.v. Vinorelbine or p.o. Vinorelbine, in combination with i.v. cisplatin.
METHODS AND RESULTS:
We reviewed two time-separated cohorts of patients referred to the Department of Oncology at Aarhus University Hospital (Denmark) from 2005 to 2012 for adjuvant chemotherapy after surgery for NSCLC. RESULTS AND Of the 265 patients included in this study, 126 patients received i.v. and 139 received p.o. Vinorelbine/cisplatin. The two groups were comparable with respect to important baseline characteristics. Median OS for all patients was 78.7 months and the median DFS was 35.7 months. No statistically significant difference in OS or DFS for patients treated with i.v. or oral Vinorelbine was detected. The DFS rates of the two groups were comparable across all variables in subgroup analysis.
CONCLUSIONS:
In conclusion we observed that intravenous or oral administration of Vinorelbine in combination with cisplatin after surgery for NSCLC appear equally effective in terms of overall and disease-free survival.
Expert Opin Pharmacother. 2014 Aug;15(11):1585-99.
Oral vinorelbine in the treatment of non-small-cell lung cancer.[Pubmed: 24972635]
Originally formulated as an intravenous (i.v.) agent, Vinorelbine is also currently available as an oral chemotherapeutic agent.
METHODS AND RESULTS:
Oral Vinorelbine has demonstrated significant activity in different settings for NSCLC, including adjuvant treatment for resected disease, concurrent chemoradiation for locally advanced NSCLC and palliative chemotherapy for recurrent/metastatic NSCLC, as part of combination schedules or as a single-agent treatment. AREAS COVERED: The authors explored the available data describing the use of oral Vinorelbine in NSCLC. PubMed articles and abstracts presented at international conferences were analysed, and relevant trials were reported and discussed. Specific settings, including the treatment of elderly and unfit patients and metronomic schedules including oral Vinorelbine, were evaluated. Available pharmacoeconomic data were also assessed.
CONCLUSIONS:
Oral Vinorelbine is an appealing agent, particularly as part of combination regimens containing platinum derivatives, although it can have a role as a single-agent treatment as well. Its safety profile is generally favourable and its route of administration is generally preferred by patients receiving chemotherapy. Compared to i.v. Vinorelbine and other antineoplastic agents, oral Vinorelbine has been reported to be advantageous in terms of cost savings.
Vinorelbine Description
Source: The herbs of Catharanthus roseus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Securoside A

Catalog No: CFN95294
CAS No: 107172-40-7
Price: $318/5mg
New compound 6

Catalog No: CFN95259
CAS No: N/A
Price: $413/5mg
1-Isomangostin

Catalog No: CFN95114
CAS No: 19275-44-6
Price: $318/5mg
Marginatoxin

Catalog No: CFN95174
CAS No: 1422536-56-8
Price: $318/10mg
Theaflavanoside II

Catalog No: CFN95380
CAS No: 943785-09-9
Price: $318/5mg
(3beta,22alpha)-26-(beta-glucopyra...

Catalog No: CFN95321
CAS No: 107783-53-9
Price: $318/20mg
Formononetin-8-C-beta-D-apiofurano...

Catalog No: CFN95157
CAS No: 1147858-78-3
Price: $318/10mg
Methyl lucidenate E2

Catalog No: CFN95569
CAS No: 98665-12-4
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2838 mL 6.4191 mL 12.8381 mL 25.6762 mL 32.0953 mL
5 mM 0.2568 mL 1.2838 mL 2.5676 mL 5.1352 mL 6.4191 mL
10 mM 0.1284 mL 0.6419 mL 1.2838 mL 2.5676 mL 3.2095 mL
50 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.5135 mL 0.6419 mL
100 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.2568 mL 0.321 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
AAPS PharmSciTech. 2014 Oct;15(5):1138-48.
A new lipid-based nano formulation of vinorelbine.[Pubmed: 24871553]
Vinorelbine (VLB) is a semi-synthetic Vinca alkaloid which is currently used in treatment of different cancer types mainly advanced breast cancer (ABC) and advanced/metastatic non-small cell lung cancer (NSCLC). However, its marketed formulation has been reported to have serious side effects, such as granulocytopenia, which is the major dose-limiting toxicity. Other unwanted effects include venous discoloration and phlebitis proximal to the site of injection, as well as localized rashes and urticaria, blistering, and skin sloughing.
METHODS AND RESULTS:
Our long-term aim in synthesizing a novel nanomicellar Vinorelbine formulation is to reduce or even eliminate these side effects and increase drug activity by formulating the drug in a lipid-based system as a nanomedicine targeted to the site of action. To this end, the purpose of this study was to prepare, characterize, and determine the in vitro efficacy of Vinorelbine-loaded sterically stabilized, biocompatible, and biodegradable phospholipid nanomicelles (SSM; size, ∼15 nm). Our results indicated that Vinorelbine incorporate at high quantities and within the interface between the core and palisade sections of the micelles. Incorporation ratio of drug within sterically stabilized micelles increased as the total amount of drug in the system increased, and no drug particles were formed at the highest drug concentrations tested. The nanomicellar formulation of Vinorelbine was ∼6.7-fold more potent than Vinorelbine dissolved in DMSO on MCF-7 cell line.
CONCLUSIONS:
Collectively, these data indicate that Vinorelbine-loaded SSM can be developed as a new, safe, stable, and effective nanomedicine for the treatment of breast and lung cancers.
Saikosaponin A

Catalog No: CFN99987
CAS No: 20736-09-8
Price: $80/20mg
Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg
Jujuboside D

Catalog No: CFN98103
CAS No: 194851-84-8
Price: $360/10mg
Crocin I

Catalog No: CFN99927
CAS No: 94238-00-3
Price: $100/20mg
Ophiopogonin D

Catalog No: CFN98156
CAS No: 41753-55-3
Price: $248/20mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
Hotrienol

Catalog No: CFN99583
CAS No: 20053-88-7
Price: $ / mg
Ginsenoside Rd2 (Quinquenoside L10)

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Tags: buy Vinorelbine | Vinorelbine supplier | purchase Vinorelbine | Vinorelbine cost | Vinorelbine manufacturer | order Vinorelbine | Vinorelbine distributor