| Structure Identification: |
| Org Biomol Chem. 2003 Apr 21;1(8):1292-7. | | Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata.[Pubmed: 12929658] |
METHODS AND RESULTS:
The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, Voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the previously known, biologically active bisindole, conophylline and its congener, conofoline. The structures of the new alkaloids were established by spectroscopic methods.
CONCLUSIONS:
The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression. | | Natural Product Letters, 1996 , 8 (1) :49-53. | | Voafinidine and Voalenine, Novel Indoles of the Aspidosperma-type from Tabernaemontana[Reference: WebLink] | | Novel indole alkaloids of the aspidosperma-type, viz., Voafinidine and voalenine were obtained in minor amounts from the leaf extract of Tabernaemontana divaricata (double flower variety). The structures of these alkaloids were elucidated by spectral methods. |
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