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    CAS No. 64190-94-9 Price
    Catalog No.CFN96395Purity>=98%
    Molecular Weight271.3Type of CompoundAlkaloids
    FormulaC16H17NO3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Zanthobungeanine Description
    Source: The roots of Zanthoxylum nitidum.
    Biological Activity or Inhibitors: 1. Zanthobungeanine shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell.
    2. Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.
    3. Zanthobungeanine shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF).
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.686 mL 18.4298 mL 36.8596 mL 73.7191 mL 92.1489 mL
    5 mM 0.7372 mL 3.686 mL 7.3719 mL 14.7438 mL 18.4298 mL
    10 mM 0.3686 mL 1.843 mL 3.686 mL 7.3719 mL 9.2149 mL
    50 mM 0.0737 mL 0.3686 mL 0.7372 mL 1.4744 mL 1.843 mL
    100 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.7372 mL 0.9215 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Zanthobungeanine References Information
    Citation [1]

    Anti-tumor Pharmacy, 2011,1(1) :30-2.

    Inhibitory action of nitidine and zanthobungeanine on lung adenocarcinoma A549 cell[Reference: WebLink]
    To determine the inhibition of nitidine and Zanthobungeanine on the lung adenocarcinoma A549 cell.Method The IC50 of nitidine and Zanthobungeanine were evaluated by MTT photocolorimetric method and the apoptosis was evaluated by inverted microscope.Results The IC_(50) of nitidine was 0.68μg·mL~(-1) and the IC_(50) of Zanthobungeanine was 173.41μg·mL~(-1).The nitidine 1.015μg·mL~(-1) induced apoptosis of 66%of lung adenocarcinoma A549 cells.The typical apoptic morphological changes,including cell shrinkage,nuclear condensation,and nuclear fragment was observed under light microscope.Conclusion Nitidine can kill the external A549 cell and inhibit the development of A549 cell,but Zanthobungeanine showed the inhibitory action only in high concentration and had no antipersonnel effect on A549 cell.Nitidine can inhibit the proliferation of lung adenocarcinoma A549 cell by inducing apoptosis.Zanthobungeanine didn't show such action.
    Citation [2]

    Journal of Shenyang Pharmaceutical University, 2013,30(2) :100-5.

    Isolation,identification and activity determination on the anti-inflammatory components of roots of Zanthoxylum nitidum[Reference: WebLink]
    To study the chemical constituents of Zanthoxylum nitidum(Roxb.)DC.and find compounds with anti-inflammatory activity.Methods Silica gel column chromatography,RP-ODS,Sephadex LH-20 and high performance liquid chromatography were applied for the isolation and purification of the constituents.The structures were elucidated by their physicochemical properties and spectral methods.,The inhibitory activity on NO production and cell survival was evaluated by MTT assay through measuring the absorbance using microplate reader.Results Thirteen compounds were isolated,including skimmianine(1),dictamnine(2),Zanthobungeanine(3),zanthodioline(4),N-methylflindersine(5),liriodenine(6),L-sesamin(7),β-amyrin(8),stigmast-9(11)-en-3-ol(9),tridecane amine(10),tetradecane amine(11),heptadecanoic amine(12)and nonadecane amine(13).Conclusions Compounds 3,4,8,10,11,12 and 13 are all isolated from Zanthoxylum nitidum for the first time.Compound 3 shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg · L-1.
    Citation [3]

    Journal of Plant Resources & Environment, 1993,2(2):25-7.

    The active constituents of platelet-activating factor (PAF) inhibitors from Zanthoxylum planispinum Sieb. et Zucc[Reference: WebLink]
    Five compounds were isolated from the petroleum ether and methylene chloride extracts of the roots and stems of Zanthoxylum planispinum Sieb. et Zucc. (Rutaceae). The structure of these compounds were determined on the basis of physical constant and UV, IR, ~1HNMR, MS spectral analysis. They are β-amyrin ( I ) , β-sitosterol ( Ⅱ ) , L-asarinin ( I ) , L-planinin ( IV ) and Zanthobungeanine ( V ) respectively. Compound I 、 IV 、 V showed obviously inhibitoryactivity to platelet aggregation caused by PAF, among them compound Ⅲ was less active than compound V , compound V was the least. Zanthobungeanine was isolated for the first time from this plant.