1. Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
2. Loureirin B is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and Loureirin B may be the cellular and molecular basis of SD-mediated immunosuppression.
3. Loureirin B is the effective component in dragon's blood modulating sodium currents in trigeminal ganglion neurons; can evoke the elevation of [Ca(2+)](i) in a dose-dependent manner.