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  • Bioactive Products
    Catalog No. Information
    CFN98173 Loureirin B

    1. Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.
    2. Loureirin B is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and Loureirin B may be the cellular and molecular basis of SD-mediated immunosuppression.
    3. Loureirin B is the effective component in dragon's blood modulating sodium currents in trigeminal ganglion neurons; can evoke the elevation of [Ca(2+)](i) in a dose-dependent manner.