1. Cuniloside B shows anti-leishmanial activity.
1. Camaric acid, lantanilic acid, and oleanolic acid possess nematicidal activity, they exhibit 95%, 98% and 70% mortality respectively against root-knot nematode Meloidogyne incognita at 0.5% concentration.
2. Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity.
3. Camaric acid shows anticancer activity.
4. Camaric acid shows significant topical anti-inflammatory activity with IC50 value of 0.67 mg/ear in the assay of TPA mouse ear oedema model.
1. Linalool possesses anti-inflammatory, antinociceptive, and other bioactive properties; it can attenuate the production of LPS-induced tumor necrosis-α and interleukin-6 bothand, block the phosphorylation of IκBαprotein, p38, c-Jun terminal kinase, and extracellular signal-regulated kinase in LPS-stimulated RAW 264.7 cells.
2. Linalool-rich essential oil is a strikingly potent leishmanicidal plant extract (50% lethal doses, 8.3 ng/ml for promastigotes and 8.7 ng/ml for amastigotes) which inhibited the growth of L. amazonensis promastigotes at very low concentrations (MIC, 85.0 pg/ml).
3. The purified linalool fraction is only inhibitory for C. albicans.
4. Linalool has dose-dependent marked sedative effects at the central nervous system (CNS), including hypnotic, anticonvulsant and hypothermic properties, it has been suggested that these neurochemical effects might be ascribed to the local anaesthetic activity of linalool, linalool also has an inhibitory effect on the acetylcholine (ACh) release and on the channel open time in the mouse neuromuscular junction.
5. Linalool, myrcene and eucalyptol have protective effect against t -butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells, they also have insecticidal activity.
6. Inhaling linalool rich essential oils can be useful as a mean to attain relaxation and counteract anxiety.
1. Phytol has antimicrobial activity.
2. Phytol interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodiazepines effects, to produce sedative and anxiolytic activities.
3. Phytol attenuates the inflammatory response by inhibiting neutrophil migration that is partly caused by reduction in IL-1β and TNF-α levels and oxidative stress.
4. Phytol and sitosterol may have antileishmanial and cytotoxicity activities.
1. Simiarenol may have in vitro leishmanicidal activity against Leishmania donovani promastigotes.