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  • Bioactive Products
    Anti-obesity Compound Library
    A unique collection of 34 Anti-obesity natural compounds
    Catalog No: B562 Anti-obesity Compound Library
    Screening Details
    Size: 1mg/well * 34 Compounds
    2mg/well * 34 Compounds
    Catalog No. Information
    CFN99258 Galanolactone

    1. Galanolactone shows cytotoxic activity .
    2. Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors.
    3. Galanolactone exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes.
    4. Galanolactone has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
    CFN99105 Glycitin

    1. An isoflavone glycitin is isolated from the licorice, which has good inhibitory effect on α-glucosidase with IC50of 0.5646 mg·mL- 1, better than the position control acarbose.
    2. Glycitin, daidzin, and genistin may modulate differentiation of MSC to cause a lineage shift toward the osteoblast and away from the adipocytes, and could inhibit adipocytic transdifferentiation of osteoblasts, they could also be helpful in preventing the development of osteonecrosis.
    3. Glycitein has a protective effect on skin aging by inhibiting of MMP-1 and increasing of collagen through ERK/JNK/P38 down-regulation, which may be mediated by the inhibition of ERK, JNK, and p38 mitogen-activated protein kinases, suggests that glycitin is a potential agent for the treatment of skin ageing.
    4. A mixture of daidzin and glycitin has anti-obese and anti-diabetic effects on C57BL/6J mice fed with a high-fat diet by the regulation of oxidative stress .
    CFN99467 Asperuloside

    1. Asperuloside(ASP) exerts its anti-inflammatory effect in correlation with inhibition of a pro-inflammatory mediator through suppressing nuclear factor kappa-B (NF-κB) nuclear translocation and MAPK phosphorylation in a dose-dependent manner.
    2. Chronic administration of Asperuloside stimulates anti-obesity and anti-metabolic syndrome activity in HFD-fed rats across several organs, similar to Eucommia leaf extract (ELE) administration, thus, ASP may be an important ingredient of ELE.
    CFN99569 (-)-Epigallocatechin gallate

    1. (-)-Epigallocatechin gallate (EGCG), a green tea polyphenol that reduce Aβ aggregation, inhibits the aggregation of tau K18ΔK280 into toxic oligomers at ten- to hundred-fold substoichiometric concentrations, thereby rescuing toxicity in neuronal model cells.
    2. (-)-Epigallocatechin gallate treatment enduring to cardio protection at mitochondrial level.
    3. The effect of (-)-epigallocatechin gallate was independent of an intact leptin receptor;growth inhibition and regression of human prostate and breast tumors in athymic mice treated with EGCG as well as play a role in the mechanism by which EGCG inhibits cancer initiation and promotion in various animal models of cancer.
    4. Topical applications of (-)-epigallocatechin gallate (EGCG) can inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice.
    5. (-)-Epigallocatechin gallate has protective effects against βA-induced neuronal apoptosis through scavenging reactive oxygen species, which may be beneficial for the prevention of Alzheimer's disease.
    CFN99702 Zingerone

    1. Zingerone has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities.
    2. Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice.
    3. Zingerone effectively inhibits 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats.
    4. Zingerone can inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1, it could as potential phytotherapeutic agent which in future can be employed to formulate preventive strategies against biofilm associated infections caused by P.aeruginosa.
    5. Zingerone can be recommended as a supplement to shrimp feed to increase growth, immunity, and disease resistance against the pathogen, V.alginolyticus , use of zingerone as appetizer and immunostimulant in shrimp is promising.
    6. Zingerone appears to produce less lipolytic actions in adipocytes derived from the High Fat Diet (HFD)-fed rats, it may has anti-obesity actions.