1. Rhynchophylline can protect against ischemic damage, probably via regulating the Akt/mTOR pathway.
2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro.
3. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.
1. Resibufogenin has displayed great potential as a chemotherapeutic agent in oncology.
2. Resibufogenina's major metabolic pathway in the human liver is CYP3A4 dominantly mediated 5β-hydroxylation .
3. Resibufogenin can influence peak amplitude, overshoot and half-width of the evoked single action potential, and simultaneously lessen the firing rate of evoked repetitive firing.
1. Pregabalin (30 and 100mg/kg) presents central spinal but not central supraspinal antinociceptive effect and Pregabalin 100mg/kg shows peripheral antinociceptive effect.
2. Postoperative administration of Pregabalin provided significant relief of postoperative shoulder pain during earlier POD after thoracic surgery for lung cancer when received multimodal analgesia in combination with NSAIDs.
3. Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients.
4. Pregabalin may be effective for the reduction of neuropathic pain, it improves postoperative analgesia compared with placebo at the expense of increased sedation and visual disturbances.
1. Alpha-Spinasterol is characterized by good blood-brain permeability.
2. Alpha-Spinasterol is a novel efficacious and safe antagonist of the TRPV1 receptor with antinociceptive effect.
3. Alpha-Spinasterol can prevent TP-induced prostatic hyperplasia and may be beneficial in the management of benign prostatic hyperplasia.
1. Trans-Caryophyllene has a novel role in regulating GSIS in pancreatic β-cells.
2. Trans-Caryophyllene is PPAR-α agonist thus regulates cellular lipid metabolism in PPAR-α dependent manners.
3. Trans-Caryophyllene has neuroprotective effects in various neurological disorders, such as chemical induced seizure and brain damage.
4. Trans-Caryophyllene reduces both acute and chronic pain in mice, which may be mediated through the opioid and endocannabinoid systems.
5. Trans-Caryophyllene suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-κB activation in microglia, suggests be beneficial in preventing hypoxia-induced neuroinflammation.