1. Squalene can significantly suppress colonic aberrant crypt foci (ACF) formation and crypt multiplicity strengthens the hypothesis that squalene possesses chemopreventive activity against colon carcinogenesis.
2. Squalene is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and has been proposed to inhibit the farnesylation of ras oncoproteins, it can effectively inhibit NNK-induced lung tumorigenesis.
3. Squalene has cardioprotective effect, it exerts an antioxidant effect against isoproterenol- induced myocardial infarction by blocking the induction of lipid peroxidation, suggests that its cardioprotective effect may be ascribable to its antioxidant property and membrane stabilizing action.
4. Squalene may be efficacious as a cytoprotectant in cyclophosphamide-induced toxicities.
Sweroside possesses wound healing, cytoprotective, skin-whitening , anti-osteoporotic , and hepatoprotective effect. It can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells. It also shows insulin-mimicking effects on the regulation of Pck1 expression.
1. Fraxin shows free radical scavenging effect at high concentration (0.5 mM) and cell protective effect against H2O2-mediated oxidative stress; it can recovere viability of human umbilical vein endothelial cells (HUVECs) damaged by H2O2-treatment and can reduce the lipid peroxidation and the internal reactive oxygen species level elevated by H2O2 treatment.
2. Fraxin enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice.
Morin, a α-glucosidase inhibitor with an IC50 value of (4.48 ± 0.04) uM, it also exhibits inhibition in the generation of advanced glycation end products which was related to the long term complications of diabetes. Morin has anti-inflammatory and anti-oxidative effects by activating Nrf2 signal pathways and inhibiting NF-κB activation. it can be used to prevent bladder cancer, it prevents MMP-9 expression via the inhibition of transcription factors AP-1, Sp-1, and NF-κB.
Bilirubin is a tetrapyrrole and a breakdown product of heme catabolism, it is a prominent endogenous antioxidant cytoprotectant and a natural inhibitor of vascular smooth muscle cell proliferation, which has neuroprotective and anti- atherosclerosis-related diseases effects. It can act as an effective agent to reduce mortality and counteract hypotension elicited by endotoxin through mechanisms involving a decreased NOS2 induction secondary to inhibition of NAD(P)H oxidase.