• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Bioactive Products
    Catalog No. Information
    CFN99153 Glycyrrhizic acid ammonium salt

    1. Glycyrrhizic acid ammonium salt has wound healing activity.
    CFN99455 Sweroside

    1. Sweroside possesses strong hepatoprotective effect.
    2. Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.
    3. Sweroside and swertiamarine may have wound healing activity, they also have cytoprotective effects, which may cause a synergism in terms of wound healing activity of Gentian.
    4. Sweroside can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells, it may be an effective skin-whitening agent through the regulates the expression of MAP kinase and melanogenic enzymes.
    5. Sweroside and gentiopicroside suppress Pck1 expression and induce phosphorylation of components in the insulin signalling cascade, demonstrates that they show insulin-mimicking effects on the regulation of Pck1 expression.
    CFN99183 (+)-Taxifolin

    1. (+)-Taxifolin is an inhibitor of aggregation of the 42-residue amyloid β-protein, it has preventive effects against Alzheimer's disease-like pathogenesis in vivo.
    2. (+)-Taxifolin is a weak inhibitor of cytochrome b5 reduction (IC50=9.8μM).
    CFN99818 Swertiamarin

    1. Swertiamarin possesses anti-hyperglycemic, anti-hyperlipidemic, anti-diabetic activity and enhances β cell regeneration which causes reversal of diabetes.
    2. Swertiamarin possesses significant antioxidant and hepatoprotective properties against d-GalN induced hepatotoxicity given at 100 and 200 mg/kg body weight orally for 8 days, which might be due to its in vitro antioxidant activity.
    3. Swertiamarine has wound healing activity via the stimulation of collagen production and its mitotic activity, it also exhibits cytoprotective effects.
    4. Swertiamarin can significantly increase high-density lipoprotein (HDL) levels and it shows a significant lipid-lowering effect, as well as a high antiatherogenic potential, overall swertiamarin is an effective lipid-lowering lead compound and can be useful for preventing atherosclerosis.
    5. Swertiamarin possesses both peripheral and central antinociceptive activity.
    6. Swertiamarin has anti-inflammatory activity, it inhibits the development of arthritis by modulating NF-κB/IκB and JAK2/STAT3 signaling, suggests that swertiamarin acts as an anti-rheumatic agent.
    7. Swertiamarin has anti-diabetic effects, the anti-diabetic effect of swertiamarin is due to gentianine, an active metabolite of swertiamarin.
    8. Swertiamarin stimulates gastric emptying and gastrointestinal motility by inhibiting the dopamine D2 receptor.
    CFN99907 Shikonin

    1. Shikonin is a natural red naphthoquinone pigment; at present, a purified shikonin preparation is widely used in Japan for the production of medicinals, cosmetics, and some food products; in Russia, shikonin enters into the antiinflammatory ointment and cream compositions used for the treatment of burns; shikonin also possesses a broad spectrum of antimicrobial activity.
    2. Shikonin exhibits its anti-tumor activity through inhibiting cell growth and promoting apoptosis by negatively regulating PI3K/Akt signaling ,targeting mitochondrial-related signaling pathway.
    3. Shikonin can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
    4. Shikonin can suppress inflammatory reactions, the inhibition of Syk-dependent phosphorylation events might underlie the blocked histamine release from human basophils, thus contributing to the anti-inflammatory effects of shikonin.