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    1,5,6-Trihydroxy-3-methoxyxanthone
    Information
    CAS No. 50868-52-5 Price
    Catalog No.CFN89549Purity>=98%
    Molecular Weight274.22Type of CompoundXanthones
    FormulaC14H10O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    1,5,6-Trihydroxy-3-methoxyxanthone Description
    Source: The herbs of Mangifera indica
    Biological Activity or Inhibitors: 1. 1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6467 mL 18.2335 mL 36.4671 mL 72.9341 mL 91.1677 mL
    5 mM 0.7293 mL 3.6467 mL 7.2934 mL 14.5868 mL 18.2335 mL
    10 mM 0.3647 mL 1.8234 mL 3.6467 mL 7.2934 mL 9.1168 mL
    50 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.4587 mL 1.8234 mL
    100 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.7293 mL 0.9117 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    1,5,6-Trihydroxy-3-methoxyxanthone References Information
    Citation [1]

    Food Science & Biotechnology, 2013, 22(4):945-949.

    Isolation of xanthones from adventitious roots of St. John’s Wort (Hypericum perforatum L.) and their antioxidant and cytotoxic activities.[Reference: WebLink]
    In this phytochemical study, 5 xanthones, 1,3,5,6-tetrahydroxyxanthone [1], 1,5,6-Trihydroxy-3-methoxyxanthone [2], ferrxanthone [3], brasilixanthone B [4], and neolancerin [5] were isolated from adventitious roots of St. John’s wort (Hypericum perforatum L.). Compound 1–5 were evaluated for antioxidant activities using the intracellular reactive oxygen species (ROS) radical scavenging 2′,7′-dichlorfluorescein-diacetate (DCFDA) assay and for cytotoxic activity against the HL-60 human promyelocytic leukemia cells. Among them, compound 1–4 exhibited scavenging activity with inhibition values of 27.4–33.2% at 10 μM; compound 1, 2, and 4 reduced the viability of HL-60 cells significantly, with IC50 values of 31.5, 28.9, and 27.7 μM, respectively.