16-Oxocleroda-3,13E-dien-15-oic acid | CAS:117620-72-1

16-Oxocleroda-3,13E-dien-15-oic acid

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Product Name	16-Oxocleroda-3,13E-dien-15-oic acid
Price:
CAS No.:	117620-72-1
Catalog No.:	CFN96984
Molecular Formula:	C₂₀H₃₀O₃
Molecular Weight:	318.45 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The stem barks of Polyalthia longifolia (Sonn) Thw. var. pendula.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.

Targets:

Antifection

In vitro:

J Ethnopharmacol. 2015 Jul 1;169:176-82.

Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection.[Pubmed: 25914039 ]

METHODS AND RESULTS:
Bioassay guided fractionation of the extract yielded; three clerodane diterpenes [16-hydroxycleroda-3,13-dien-16,15-olide (1), 16-Oxocleroda-3,13E-dien-15-oic acid (2) and 3,16-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide (3)], a steroid [beta-stigmasterol (4)] and two alkaloids [darienine (5) and stepholidine (6)]. While compounds 4, 5 and 6 exhibited weak antiplasmodial activity (IC50 22-105μg/ml), the clerodane diterpenes exhibited significantly potent (p<0.005) blood schizonticidal activity (IC50: 3-6μg/ml). This is the first report of the antiplasmodial activity of compounds 2 and 3. In combination assay with chloroquine, compounds 1, 2, 3 and 5 antagonized the antiplasmodial activity of chloroquine while 4 and 6 demonstrated a synergistic action.
CONCLUSIONS:
The potent antiplasmodial activity of the extract of P. longifolia (Sonn) Thw. var. pendula and compounds therein strongly suggests its usefulness as an antimalarial agent and supports its inclusion or exploitation in formulations of herbal remedies for malaria in Ghana.

16-Oxocleroda-3,13E-dien-15-oic acid Description

Source:	The stem barks of Polyalthia longifolia (Sonn) Thw. var. pendula.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1402 mL	15.7011 mL	31.4021 mL	62.8042 mL	78.5053 mL
5 mM	0.628 mL	3.1402 mL	6.2804 mL	12.5608 mL	15.7011 mL
10 mM	0.314 mL	1.5701 mL	3.1402 mL	6.2804 mL	7.8505 mL
50 mM	0.0628 mL	0.314 mL	0.628 mL	1.2561 mL	1.5701 mL
100 mM	0.0314 mL	0.157 mL	0.314 mL	0.628 mL	0.7851 mL

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