|Source:||The roots of Panax ginseng C. A. Mey.|
|Biological Activity or Inhibitors:||1. 20(R)-Ginsenoside Rg3 has anti-aging and antifatigue activities.
2. 20(R)-Ginsenoside Rg3 can adjust cerebral nervous system, activating normal cell and sedation.
3. 20(R)-Ginsenoside Rg3 can prevent and treat coronary heart disease, climacteric syndrome, diabetes, anemia ,cancer, etc.
4. 20(R)-Ginsenoside Rg3 can enhance immunity; protect hematopoietic function of marrow, enhance hematopoietic ability; promote metabolism ; improving the ability of hepatic detoxifcation.
|Solvent:||Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.2739 mL||6.3693 mL||12.7385 mL||25.4771 mL||31.8463 mL|
|5 mM||0.2548 mL||1.2739 mL||2.5477 mL||5.0954 mL||6.3693 mL|
|10 mM||0.1274 mL||0.6369 mL||1.2739 mL||2.5477 mL||3.1846 mL|
|50 mM||0.0255 mL||0.1274 mL||0.2548 mL||0.5095 mL||0.6369 mL|
|100 mM||0.0127 mL||0.0637 mL||0.1274 mL||0.2548 mL||0.3185 mL|
Biol Pharm Bull. 2002 Jan;25(1):58-63.
|Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities.[Pubmed: 11824558]|
|When ginsenoside Rg3 was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside Rg3 to ginsenoside Rh2 and protopanaxadiol. The main metabolite was ginsenoside Rh2. 20(S)-ginsenoside Rg3 was quickly transformed to 20(S)-ginsenoside Rh2 or 20(S)-protopanaxadiol in an amount 19-fold that compared with the transformation of 20(R)-Ginsenoside Rg3 to 20(R)-ginsenoside Rh2 or 20(R)-protopanaxadiol.|
Biol Pharm Bull. 2008 Nov;31(11):2024-7.
|The anti-fatigue effect of 20(R)-ginsenoside Rg3 in mice by intranasally administration.[Pubmed: 18981567]|
|20(R)-Ginsenoside Rg3 (20(R)-Rg3) has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment. However, 20(R)-Ginsenoside Rg3 has a low bioavailability after oral administration in human due to the first-pass effect. Recently, nasal route has gained increasing interest as it can avoid first-pass effect for its lower enzymatic activity compared with the gastrointestinal tract and liver. In order to provide an animal experimental evidence of 20(R)-Ginsenoside Rg3 intranasal administrated preparation, the anti-fatigue effect of 20(R)-Ginsenoside Rg3 after intranasal administration was investigated. Two weeks after 20(R)-Ginsenoside Rg3 was administrated intranasally to mice at three different doses, the anti-fatigue effect of 20(R)-Ginsenoside Rg3 was evaluated by the weight-loaded swimming test and biochemical parameters related to fatigue, such as serum urea nitrogen (SUN), lactic dehydrogenase (LDH), superoxide dismutase (SOD), malondialdehyde (MDA), blood lactic acid (LA) and hepatic glycogen. Our results predicted a benefit of 20(R)-Ginsenoside Rg3 as an anti-fatigue treatment by intranasal administration. The mechanism was related to the increase of the storage of hepatic glycogen, and the decrease of the accumulation of metabolite such as lactic acid and serum urea nitrogen.|
Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Mar;36(2):217-20.
|Anticarcinogenic effect of 20(R)-ginsenoside Rg3 on induced hepatocellular carcinoma in rats[Pubmed: 15807271]|
|OBJECTIVE: To explore the anticarcinogenic mechanism of 20(R)-Ginsenoside Rg3 in induced liver tumor in SD rat. METHODS: Thirty-five SD rats with induced hepatocellular carcinoma were divided into a control group and 3 dosage groups according to the dosing levels of 20(R)-Ginsenoside Rg3. The tumour volume was measured by MR imaging. Before-after comparison showed that the anti-proliferative effects of 20(R)-Ginsenoside Rg3 were significant in three treatment groups. CONCLUSION: 20(R)-Ginsenoside Rg3 can noticeably inhibit the proliferation of tumor cells, and efficaciously induce the apoptosis and facilitate necrosis of the tumor cells, and there appears to be a dose dependent effect.|