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    4-Quinazolinone
    4-Quinazolinone
    Information
    CAS No. 491-36-1 Price
    Catalog No.CFN91938Purity>=98%
    Molecular Weight146.15Type of CompoundAlkaloids
    FormulaC8H6N2OPhysical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    4-Quinazolinone Description
    Source: The roots of Dichroa febrifuga
    Biological Activity or Inhibitors: 1. Some 4-quinazolinone derivatives have antiplatelet activity.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.8423 mL 34.2114 mL 68.4229 mL 136.8457 mL 171.0571 mL
    5 mM 1.3685 mL 6.8423 mL 13.6846 mL 27.3691 mL 34.2114 mL
    10 mM 0.6842 mL 3.4211 mL 6.8423 mL 13.6846 mL 17.1057 mL
    50 mM 0.1368 mL 0.6842 mL 1.3685 mL 2.7369 mL 3.4211 mL
    100 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.3685 mL 1.7106 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    4-Quinazolinone References Information
    Citation [1]

    Pharmazie. 1992 Feb;47(2):91-4.

    Synthesis and in vitro study of platelet antiaggregant activity of some 4-quinazolinone derivatives.[Pubmed: 1635928]
    Some new 4-Quinazolinones were prepared. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by ADP, collagen, arachidonic acid and the platelet serotonin release reaction. Most molecules showed an inhibiting power similar to that of acetylsalicylic acid under the same conditions, and even greater when aggregation was induced by ADP. Reduction of the 4-Quinazolinone derivatives to their 1,2,3,4-tetrahydroquinazoline homologues produced an increase in platelet inhibitory action except when ADP is the inductor.