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    Broussonin B
    Information
    CAS No. 73731-86-9 Price
    Catalog No.CFN97695Purity>=98%
    Molecular Weight258.32Type of CompoundPhenols
    FormulaC16H18O3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.Broussonin B also can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
    In vitro:
    Biol Pharm Bull. 2005 Sep;28(9):1798-800.
    7-hydroxy-3-(4-hydroxybenzyl)chroman and broussonin b: neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors.[Pubmed: 16141565 ]

    METHODS AND RESULTS:
    The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4'-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), Broussonin B (3), and cis-hinokiresinol (4).
    CONCLUSIONS:
    Compounds 1-3 induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, while 4 was less active. In addition, compounds 2-4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.
    Broussonin B Description
    Source: The branches of Broussonetia papyrifera.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8712 mL 19.3558 mL 38.7117 mL 77.4234 mL 96.7792 mL
    5 mM 0.7742 mL 3.8712 mL 7.7423 mL 15.4847 mL 19.3558 mL
    10 mM 0.3871 mL 1.9356 mL 3.8712 mL 7.7423 mL 9.6779 mL
    50 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.5485 mL 1.9356 mL
    100 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.7742 mL 0.9678 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Bioorg Med Chem Lett. 2012 Apr 15;22(8):2760-3.
    A new pancreatic lipase inhibitor from Broussonetia kanzinoki.[Pubmed: 22450131 ]

    METHODS AND RESULTS:
    A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), Broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7).
    CONCLUSIONS:
    Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
    Structure Identification:
    Chemistry Letters,1980,3(3):339-340.
    Broussonins A and B, new phytoalexins from diseased paper mulberry.[Reference: WebLink]

    METHODS AND RESULTS:
    Isolation and structure elucidation of two phytoalexins (1 and 2), produced by diseased paper mulberry and designated as Broussonin A and Broussonin B, are described.
    CONCLUSIONS:
    These phytoalexins are characterized structurally by a 1,3-diphenylpropane skeleton.