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    Cepharadione B
    Cepharadione B
    CAS No. 55610-02-1 Price
    Catalog No.CFN94151Purity>=98%
    Molecular Weight321.33Type of CompoundAlkaloids
    FormulaC19H15NO4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Cepharadione B Description
    Source: The roots of Stephania cepharantha Hayata
    Biological Activity or Inhibitors: 1. Cepharadione B exhibits strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
    2. Cepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1121 mL 15.5603 mL 31.1207 mL 62.2413 mL 77.8016 mL
    5 mM 0.6224 mL 3.1121 mL 6.2241 mL 12.4483 mL 15.5603 mL
    10 mM 0.3112 mL 1.556 mL 3.1121 mL 6.2241 mL 7.7802 mL
    50 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.2448 mL 1.556 mL
    100 mM 0.0311 mL 0.1556 mL 0.3112 mL 0.6224 mL 0.778 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Cepharadione B References Information
    Citation [1]

    Chem. Pharm. Bull. (Tokyo)., 2009 ,57(11):1227-30.

    The constituents and their bioactivities of Houttuynia cordata.[Pubmed: 19881272]
    Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norCepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.
    Citation [2]

    Arch. Pharm.Res., 2001, 24(6):518-21.

    Cytotoxic alkaloids from Houttuynia cordata.[Pubmed: 11794526]
    Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norCepharadione B(4), Cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.