Cytidine | CAS:65-46-3 | Manufacturer ChemFaces

Cytidine

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Size /Price /Stock	10 mM * 1 mL in DMSO / $8.9 / In-stock
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Description:

Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation.

Targets:

HIV

In vitro:

RNA. 2001 Mar; 7(3): 395–404.

The effect of cytidine on the structure and function of an RNA ligase ribozyme.[Pubmed: 11333020]

METHODS AND RESULTS:
A Cytidine-free ribozyme with RNA ligase activity was obtained by in vitro evolution, starting from a pool of random-sequence RNAs that contained only guanosine, adenosine, and uridine. This ribozyme contains 74 nt and catalyzes formation of a 3',5'-phosphodiester linkage with a catalytic rate of 0.016 min(-1). The RNA adopts a simple secondary structure based on a three-way junction motif, with ligation occurring at the end of a stem region located several nucleotides away from the junction. Cytidine was introduced to the Cytidine-free ribozyme in a combinatorial fashion and additional rounds of in vitro evolution were carried out to allow the molecule to adapt to this added component. The resulting Cytidine-containing ribozyme formed a 3',5' linkage with a catalytic rate of 0.32 min(-1).
CONCLUSIONS:
The improved rate of the Cytidine-containing ribozyme was the result of 12 mutations, including seven added Cytidines, that remodeled the internal bulge loops located adjacent to the three-way junction and stabilized the peripheral stem regions.

Cytidine Description

Source:	The peels of Punica granatum L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Journal of Virology, 2007 , 81 (13) :7238.

Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation[Reference: WebLink]

APOBEC3G (A3G) is a single-stranded DNA Cytidine deaminase that targets retroviral minus-strand DNA and has potent antiviral activity against diverse retroviruses. However, the mechanisms of A3G antiviral functions are incompletely understood.
METHODS AND RESULTS:
Here we demonstrate that A3G, A3F, and, to a lesser extent, the noncatalytic A3GC291S block human immunodeficiency virus type 1 (HIV-1) replication by interfering with proviral DNA formation. In HIV-1 virions, A3G interacted with HIV-1 integrase and nucleocapsid, key viral factors for reverse transcription and integration. Unlike A3G, the weak antiviral A3C Cytidine deaminase did not interact with either of these factors and did not affect viral reverse transcription or proviral DNA formation.
CONCLUSIONS:
Thus, multiple steps of the HIV-1 replication cycle, most noticeably the formation of proviral DNA, are inhibited by both Cytidine deamination-dependent and -independent mechanisms.

Product Name	Cytidine
Price:	$30 / 20mg
CAS No.:	65-46-3
Catalog No.:	CFN92490
Molecular Formula:	C₉H₁₃N₃O₅
Molecular Weight:	243.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The peels of Punica granatum L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Alkaloids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1118 mL	20.5592 mL	41.1184 mL	82.2368 mL	102.7961 mL
5 mM	0.8224 mL	4.1118 mL	8.2237 mL	16.4474 mL	20.5592 mL
10 mM	0.4112 mL	2.0559 mL	4.1118 mL	8.2237 mL	10.2796 mL
50 mM	0.0822 mL	0.4112 mL	0.8224 mL	1.6447 mL	2.0559 mL
100 mM	0.0411 mL	0.2056 mL	0.4112 mL	0.8224 mL	1.028 mL

CFN98806	Thymidine	50-89-5	242.2	C₁₀H₁₄N₂O₅
CFN97557	Allantoin	97-59-6	158.1	C₄H₆N₄O₃
CFN93213	Streptozotocin	18883-66-4	265.22	C₈H₁₅N₃O₇
CFN98552	Folic acid	59-30-3	441.4	C₁₉H₁₉N₇O₆
CFN92944	Thermopsidine	492-02-4	406.52	C₂₄H₃₀N₄O₂
CFN96780	Lumichrome	1086-80-2	242.23	C₁₂H₁₀N₄O₂
CFN99992	Indigo	482-89-3	262.26	C₁₆H₁₀N₂O₂
CFN90007	5-Aza-2'-deoxycytidine	2353-33-5	228.21	C₈H₁₂N₄O₄
CFN92490	Cytidine	65-46-3	243.2	C₉H₁₃N₃O₅
CFN91543	2'-Deoxycytidine	951-77-9	227.2	C₉H₁₃N₃O₄