• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Epimagnolin A
    Epimagnolin A
    Information
    CAS No. 41689-51-4 Price
    Catalog No.CFN90949Purity>=98%
    Molecular Weight416.46Type of CompoundLignans
    FormulaC23H28O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Univerzita Karlova v Praze (Czech Republic)
  • Tokyo Woman's Christian University (Japan)
  • Mendel University in Brno (Czech Republic)
  • Kyushu University (Japan)
  • John Innes Centre (United Kingdom)
  • Chulalongkorn University (Thailand)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Eastern Finland (Finland)
  • University of Liège (Belgium)
  • University Medical Center Mainz (Germany)
  • University of Hawaii Cancer Center (USA)
  • More...
  • Package
    Featured Products
    Terrestrosin K

    Catalog No: CFN90822
    CAS No: 193605-07-1
    Price: $268/10mg
    Morusin

    Catalog No: CFN97083
    CAS No: 62596-29-6
    Price: $128/20mg
    Zederone

    Catalog No: CFN92616
    CAS No: 7727-79-9
    Price: $338/20mg
    Acetylshikonin

    Catalog No: CFN90308
    CAS No: 54984-93-9
    Price: $418/20mg
    3,6'-Disinapoyl sucrose

    Catalog No: CFN90578
    CAS No: 139891-98-8
    Price: $138/20mg
    Epimagnolin A Description
    Source: The dried flower buds of Magnolia biondii Pamp.
    Biological Activity or Inhibitors: 1. Epimagnolin A affects the transport activity of ABCB1(a major transmembrane efflux pump belonging to the ABC transporter superfamily).
    2. (+)-Epimagnolin A exhibits growth inhibitory activity against larvae of Drosophila melanogaster.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4012 mL 12.006 mL 24.0119 mL 48.0238 mL 60.0298 mL
    5 mM 0.4802 mL 2.4012 mL 4.8024 mL 9.6048 mL 12.006 mL
    10 mM 0.2401 mL 1.2006 mL 2.4012 mL 4.8024 mL 6.003 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9605 mL 1.2006 mL
    100 mM 0.024 mL 0.1201 mL 0.2401 mL 0.4802 mL 0.6003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Epimagnolin A References Information
    Citation [1]

    J Sep Sci. 2007 Oct;30(15):2370-81.

    Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction.[Pubmed: 17628872]
    The dried flower buds of Magnolia biondii Pamp are one of the most widely used medicinal plants officially listed in the Chinese Pharmacopoeia. A 2-D column-switching system without sample loop trapping, where two columns were switched directly via a six-port two-position switching valve, was successfully applied for the first time to the isolation and purification of five lignans including pinoresinol dimethyl ether, magnolin, Epimagnolin A, fargesin, and demethoxyaschantin from M. biondii Pamp after microwave-assisted extraction. The introduction of the six-port switching valve instead of sample loop assured 100% recovery from the first dimension to the second, and the injection volumes of the second dimension could reach 12 mL. In this mode of operation, the solvent consumption of the 2-D approach was less than 30% that of conventional gradient methods with even larger sample size. The simultaneous operations of the two dimensions allowed the cycle time to be less than 16 min, compared to 90 min in the gradient elution single-dimension mode of operation. All of the five lignans were isolated at high purities of over 99% with approximately 95% recoveries.
    Citation [2]

    Planta Med 2016; 82(S 01): S1-S381.

    Preparation of epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia sp., and evaluation of anti-drug-resistance activity.[Reference: WebLink]
    We examined the possibility of interaction between Epimagnolin A and human multidrug resistance protein ABCB1, a major transmembrane efflux pump belonging to the ABC transporter superfamily. In the calcein and ATPase assay [1], Epimagnolin A inhibited the extrusion of calcein by Flp-In-293/ABCB1 cells and stimulated the ATPase activity of ABCB1, respectively, in a concentration-dependent manner. It showed saturation kinetics between compound-stimulated ATPase activity and compound concentration, suggesting Michaelis-Menten kinetics similar to control drug, verapamil. The Km and Vmax values were calculated from Hanes-Woolf plots; epimagnolin, Km = 42.9 ± 7.53μM and Vmax = 156 ± 15.0μM and verapamil, Km = 12.3 ± 4.79μM and Vmax = 109 ± 3.18μM. In the MTT assay, the sensitivities of the Flp-In-293/ABCB1 cells to anti-cancer drugs were enhanced in the presence of 10μM Epimagnolin A. The present study results indicate that Epimagnolin A affects the transport activity of ABCB1.
    Citation [3]

    Phytochemistry, 1994, 35(00):611–613.

    An insect growth inhibitory lignan from flower buds of Magnolia fargesii.[Reference: WebLink]
    Bioassay-guided isolation afforded a new lignan, (+)-Epimagnolin A, from the flower buds of Magnolia fargesii. This lignan exhibited growth inhibitory activity against larvae of Drosophila melanogaster. The structure of a new lignan was determined on the basis of spectral methods.