Harmine hydrochloride | CAS:343-27-1 | Manufacturer ChemFaces

Harmine hydrochloride

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	Harmine hydrochloride
Price:	$40 / 20mg
CAS No.:	343-27-1
Catalog No.:	CFN90341
Molecular Formula:	C₁₃H₁₂N₂O.HCl
Molecular Weight:	248.71 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Peganum harmala L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $8.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation.

Targets:

Akt

In vitro:

J Neurooncol. 2013 Mar;112(1):39-48.

Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[Pubmed: 23392846]

Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases.
METHODS AND RESULTS:
In this study, we found that Harmine hydrochloride clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Harmine hydrochloride had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Harmine hydrochloride inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Harmine hydrochloride decreased the tumorigenicity of GSLCs.
CONCLUSIONS:
Thus we conclude that Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Harmine hydrochloride may act as a new approach to glioblastoma treatment.

Harmine hydrochloride Description

Source:	The herbs of Peganum harmala L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Alkaloids Compound Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0207 mL	20.1037 mL	40.2075 mL	80.4149 mL	100.5187 mL
5 mM	0.8041 mL	4.0207 mL	8.0415 mL	16.083 mL	20.1037 mL
10 mM	0.4021 mL	2.0104 mL	4.0207 mL	8.0415 mL	10.0519 mL
50 mM	0.0804 mL	0.4021 mL	0.8041 mL	1.6083 mL	2.0104 mL
100 mM	0.0402 mL	0.201 mL	0.4021 mL	0.8041 mL	1.0052 mL

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CFN92206	7-Hydroxy-beta-carboline-1-propionic acid	215934-15-9	256.3	C₁₄H₁₂N₂O₃
CFN92746	Ethyl beta-carboline-1-propionate	90686-24-1	268.3	C₁₆H₁₆N₂O₂
CFN99002	Beta-Carboline-1-propanoic acid	89915-39-9	240.3	C₁₄H₁₂N₂O₂
CFN92747	Infractin	91147-07-8	254.3	C₁₅H₁₄N₂O₂
CFN99098	Harmalidine	109794-97-0	254.3	C₁₆H₁₈N₂O
CFN90499	Strictosidine	20824-29-7	530.57	C₂₇H₃₄N₂O₉
CFN96092	Harman	486-84-0	182.2	C₁₂H₁₀N₂
CFN92411	N9-Methylharman	16498-64-9	196.3	C₁₃H₁₂N₂