Science | Nature | Cell | View More
Natural Products
Kongensin A
Kongensin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kongensin A
Price:
CAS No.: 885315-96-8
Catalog No.: CFN97452
Molecular Formula: C22H30O5
Molecular Weight: 374.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Croton cascarilloides
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Chang Gung University (Taiwan)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Universidad de Ciencias y Artes... (Mexico)
  • University of Queensland (Australia)
  • CSIRO - Agriculture Flagship (Australia)
  • St. Jude Children Research Hosp... (USA)
  • University of Pretoria (South Africa)
  • Srinakharinwirot University (Thailand)
  • Hamdard University (India)
  • Universite de Lille1 (France)
  • Seoul National University of Sc... (Korea)
  • More...
Package
Featured Products
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Linoleic acid

Catalog No: CFN93168
CAS No: 60-33-3
Price: $30/20mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
Naringin

Catalog No: CFN99555
CAS No: 10236-47-2
Price: $30/20mg
Pseudoaspidin

Catalog No: CFN90684
CAS No: 478-28-4
Price: $138/20mg
Sageone

Catalog No: CFN92166
CAS No: 142546-15-4
Price: $ / mg
Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg
Nordihydrocapsaicin

Catalog No: CFN90241
CAS No: 28789-35-7
Price: $268/20mg
(+)-Epipinoresinol

Catalog No: CFN92288
CAS No: 24404-50-0
Price: $338/5mg
Rhynchophylline

Catalog No: CFN98131
CAS No: 76-66-4
Price: $98/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
Targets: HSP (e.g. HSP90)
In vitro:
.Cell Chem Biol. 2016 Feb 18;23(2):257-66.
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.[Pubmed: 27028885 ]
RIP3-dependent necroptosis has recently garnered significant interest because of the unique signaling mechanisms and pathologic functions involved in this process. Accordingly, a number of chemical screens have identified several effective small-molecule inhibitors that specifically block necroptosis.
METHODS AND RESULTS:
Here, we report the discovery that Kongensin A (KA), a natural product isolated from Croton kongensis, is a potent inhibitor of necroptosis and an inducer of apoptosis. Using a new bioorthogonal ligation method (TQ ligation), we reveal that the direct cellular target of KA is heat shock protein 90 (HSP90). Further studies demonstrate that KA covalently binds to a previously uncharacterized cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37, which leads to inhibition of RIP3-dependent necroptosis and promotion of apoptosis in multiple cancer cell lines.
CONCLUSIONS:
Collectively, our findings demonstrate that KA is an effective HSP90 inhibitor that has potential anti-necroptosis and anti-inflammation applications.
Kongensin A Description
Source: The herbs of Croton cascarilloides
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3'-Hydroxymirificin

Catalog No: CFN95102
CAS No: 168035-02-7
Price: $338/5mg
(3beta,22alpha)-26-(beta-glucopyra...

Catalog No: CFN95321
CAS No: 107783-53-9
Price: $318/20mg
2,6-Dihydroxyacetophenone-4-O-[4',...

Catalog No: CFN95470
CAS No: 1781226-44-5
Price: $318/5mg
Spinacetin

Catalog No: CFN95194
CAS No: 3153-83-1
Price: $318/5mg
Scoparin

Catalog No: CFN95544
CAS No: 301-16-6
Price: $318/5mg
Clemastanin B

Catalog No: CFN95064
CAS No: 112747-98-5
Price: $368/20mg
Angelol M

Catalog No: CFN95060
CAS No: 1092952-64-1
Price: $288/5mg
Ginsenoside F5

Catalog No: CFN95034
CAS No: 189513-26-6
Price: $298/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6702 mL 13.3511 mL 26.7023 mL 53.4045 mL 66.7557 mL
5 mM 0.534 mL 2.6702 mL 5.3405 mL 10.6809 mL 13.3511 mL
10 mM 0.267 mL 1.3351 mL 2.6702 mL 5.3405 mL 6.6756 mL
50 mM 0.0534 mL 0.267 mL 0.534 mL 1.0681 mL 1.3351 mL
100 mM 0.0267 mL 0.1335 mL 0.267 mL 0.534 mL 0.6676 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Dehydrocostus lactone

Catalog No: CFN98720
CAS No: 477-43-0
Price: $40/20mg
Linoleic acid

Catalog No: CFN93168
CAS No: 60-33-3
Price: $30/20mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
Naringin

Catalog No: CFN99555
CAS No: 10236-47-2
Price: $30/20mg
Pseudoaspidin

Catalog No: CFN90684
CAS No: 478-28-4
Price: $138/20mg
Sageone

Catalog No: CFN92166
CAS No: 142546-15-4
Price: $ / mg
Procyanidin B1

Catalog No: CFN99557
CAS No: 20315-25-7
Price: $238/20mg
Nordihydrocapsaicin

Catalog No: CFN90241
CAS No: 28789-35-7
Price: $268/20mg
(+)-Epipinoresinol

Catalog No: CFN92288
CAS No: 24404-50-0
Price: $338/5mg
Rhynchophylline

Catalog No: CFN98131
CAS No: 76-66-4
Price: $98/20mg
Tags: buy Kongensin A | Kongensin A supplier | purchase Kongensin A | Kongensin A cost | Kongensin A manufacturer | order Kongensin A | Kongensin A distributor