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    Primin
    Primin
    Information
    CAS No. 15121-94-5 Price
    Catalog No.CFN90588Purity> 98%
    Molecular Weight208.26Type of CompoundQuinones
    FormulaC12H16O3Physical DescriptionOil
    Download     COA    MSDS    SDFSimilar structuralComparison
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    Primin Description
    Source: The fruits of Vaccinium Spp
    Biological Activity or Inhibitors: 1. Primin has antimycobacterial action.
    2. Primin has strong antineoplastic action.
    3. Primin can serve as a lead compound for the rational design of more potent and less toxic antiprotozoal agents.
    4. Primin has potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and low cytotoxicity (IC50 15.4 microM) on mammalian cells.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8017 mL 24.0085 mL 48.0169 mL 96.0338 mL 120.0423 mL
    5 mM 0.9603 mL 4.8017 mL 9.6034 mL 19.2068 mL 24.0085 mL
    10 mM 0.4802 mL 2.4008 mL 4.8017 mL 9.6034 mL 12.0042 mL
    50 mM 0.096 mL 0.4802 mL 0.9603 mL 1.9207 mL 2.4008 mL
    100 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9603 mL 1.2004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Primin References Information
    Citation [1]

    Chem Biodivers. 2006 Nov;3(11):1230-7.

    Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies.[Pubmed: 17193236]
    Primin (=2-methoxy-6-pentylcyclohexa-2,5-diene-1,4-dione), a natural benzoquinone synthesized in our laboratory, was investigated for its in vitro antiprotozoal, antimycobacterial, and cytotoxic potential. Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells. Only moderate inhibitory activity was observed against Mycobacterium tuberculosis, Trypanosoma cruzi, and Plasmodium falciparum. When tested for in vivo efficacy in a Trypanosoma b. brucei rodent model, Primin failed to cure the infection at 20 mg/kg given intraperitoneally. Primin was too toxic in vivo at a higher concentration (30 mg/kg, injected i.p. route) in mice infected with L. donovani. Taken together, Primin can serve as a lead compound for the rational design of more potent and less toxic antiprotozoal agents.
    Citation [2]

    Med Chem. 2007 Jul;3(4):369-72.

    Synthesis and antitumour activity of the Primin (2-methoxy-6-n-pentyl-1,4-benzoquinone) and analogues.[Pubmed: 17627574]
    Cancer is a serious worldwide health threat, killing almost seven million people per year. Quinones are an important class of antitumour agents that are activated by tumour hypoxia. Primin (2-methoxy-6-n-pentyl-1,4-benzo-quinone), a naturally-occurring product obtained from Primula obconica (Primulaceae) has shown antimicrobial and antitumour properties. The synthesis of the Primin to obtain 3-, 5- or 6-alkyl substituted derivatives has been previously attempted seeking antitumour activity.
    Citation [3]

    Rev Inst Antibiot (Recife). 1974 Dec;14(1-2):9-16.

    First observations on the topical use of Primin, Plumbagin and Maytenin in patients with skin cancer.[Pubmed: 4620478]
    Eleven cases of patients bearing basic cellular carcinoma, and one case of patient bearing Kaposi's sarcomatosis, all treated with antibiotics isolated by Goncalves de Lima and Co-workers at the Instituto de Antibióticos, are presented by the authors. Primin, an antibiotic extracted from a vegetal named Miconia sp. (Herb. I.A.-1903) with a 2-metoxi-6-n-pentil-p benzoquinone structure, presented a strong antineoplastic action in the cases treated.