Sodium cholate | CAS:361-09-1 | Manufacturer ChemFaces

Sodium cholate

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Description:

Sodium cholate (Cholic acid) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.

Targets:

HIV

In vivo:

Hum. Reprod.,1993 Jun;8(6):866-9.

Spermicidal and antiviral properties of cholic acid: contraceptive efficacy of a new vaginal sponge (Protectaid) containing sodium cholate.[Pubmed: 7688380]

METHODS AND RESULTS:
Cholic acid (Sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. The same effects are observed for F-5 Gel, the active mixture of a new contraceptive sponge (Protectaid), which contains Sodium cholate together with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride. Both cholic acid and the F-5 Gel exerted a dose-dependent, in-vitro inhibitory effect 1) on the activity of HIV-1 associated reverse transcriptase in an acellular system (their 50% inhibitory dose was 7.2 mM and 0.8 x 10 -3 v/v, respectively, and 2) on the potential of HIV-1 to infect human lymphocytes efficiently. In the 3 semen samples examined, sperm motility was instantaneously inhibited by the addition of a 6 mM solution of Sodium cholate or of a 1:10 dilution of F-5 Gel. Both cholic acid and F-5 Gel affected in a dose-dependent manner the viability of normal peripheral blood lymphocytes (NPBL) and CEM cells. The Protectaid contraceptive sponge impregnated with F-5 Gel was given to 20 young women aged 19-25 years for a period of 1 year who had chosen this method for both contraception and against sexually transmitted diseases. All women were instructed to insert the sponge within the 12 hours preceding each sexual intercourse and to remove it 4-6 hours afterwards. During 12 months of use with at least 3 intercourse per week, the contraceptive efficacy of the Protectaid vaginal sponge was 100%. Cervical cultures at 6-month intervals showed the presence of Mycoplasma hominis and Candida albicans in 1 and 2 cases, respectively.
CONCLUSIONS:
The combined spermicidal and anti-HIV properties of cholic acid reported and used in the Protectaid sponge offer a new and modern protective method of contraception. At the end of the study, cervical cultures revealed the presence of Escherichia coli and Candida albicans in 1 case each. No slide effects were recorded, and only 1 woman complained of discomfort.

Sodium cholate Description

Source:	The bile of pig.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Diamond & Related Materials, 2007, 16(1):12-15.

Electrochemical behavior of sodium cholate and deoxycholate on an electrode modified with multi-walled carbon nanotubes (MWNTs) linked up with cyclodextrin[Reference: WebLink]

METHODS AND RESULTS:
The electrochemical behavior of Sodium cholate (CA) and deoxycholate (DCA) was investigated on ITO electrodes coated with β-cyclodextrin (β-CD) modified multi-walled carbon nanotubes (MWNTs) in aqueous solution. β-CD modified MWNTs (MWNT–CDs) showed electrocatalytic effect on the reduction of CA, while electrochemical response of DCA was not observed. To further understand the mechanism of the electrochemical process, the electrochemical behavior of CA and DCA on bare ITO electrode and the electrode modified with MWNTs possessing carboxyl groups (MWNT–COOHs) was also discussed.
CONCLUSIONS:
The results indicate that the electrochemical response of CA can be improved through the use of carbon nanotubes. The introduction of cyclodextrin moieties enhances the selectivity of the electrodes to CA and DCA.

Product Name	Sodium cholate
Price:
CAS No.:	361-09-1
Catalog No.:	CFN96673
Molecular Formula:	C₂₄H₃₉NaO₅
Molecular Weight:	430.55 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The bile of pig.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Antifertility Compound Library Steroids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3226 mL	11.6131 mL	23.2261 mL	46.4522 mL	58.0653 mL
5 mM	0.4645 mL	2.3226 mL	4.6452 mL	9.2904 mL	11.6131 mL
10 mM	0.2323 mL	1.1613 mL	2.3226 mL	4.6452 mL	5.8065 mL
50 mM	0.0465 mL	0.2323 mL	0.4645 mL	0.929 mL	1.1613 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	0.4645 mL	0.5807 mL

CFN89170	Lithocholic acid	434-13-9	376.58	C₂₄H₄₀O₃
CFN96673	Sodium cholate	361-09-1	430.55	C₂₄H₃₉NaO₅
CFN96947	Glycodeoxycholic acid	360-65-6	449.63	C₂₆H₄₃NO₅
CFN89075	Glycoursodeoxycholic acid	64480-66-6	449.63	C₂₆H₄₃NO₅
CFN96646	Taurocholic acid	81-24-3	515.70	C₂₆H₄₅NO₇S
CFN96645	Tauroursodeoxycholic acid	14605-22-2	499.70	C₂₆H₄₅NO₆S
CFN80241	Sodium taurochenodeoxycholate	6009-98-9	521.68	C₂₆H₄₄NNaO₆S
CFN96464	Ursodeoxycholic acid	128-13-2	392.58	C₂₄H₄₀O₄
CFN90478	Chenodeoxycholic acid	474-25-9	392.57	C₂₄H₄₀O₄
CFN99796	Cholic acid	81-25-4	408.57	C₂₂H₄₀O₅