|Source:||The bile of pig.|
|Biological Activity or Inhibitors:|| 1. Sodium cholate (Cholic acid) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.3226 mL||11.6131 mL||23.2261 mL||46.4522 mL||58.0653 mL|
|5 mM||0.4645 mL||2.3226 mL||4.6452 mL||9.2904 mL||11.6131 mL|
|10 mM||0.2323 mL||1.1613 mL||2.3226 mL||4.6452 mL||5.8065 mL|
|50 mM||0.0465 mL||0.2323 mL||0.4645 mL||0.929 mL||1.1613 mL|
|100 mM||0.0232 mL||0.1161 mL||0.2323 mL||0.4645 mL||0.5807 mL|
Hum. Reprod.,1993 Jun;8(6):866-9.
|Spermicidal and antiviral properties of cholic acid: contraceptive efficacy of a new vaginal sponge (Protectaid) containing sodium cholate.[Pubmed: 7688380]|
|Cholic acid (Sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. The same effects are observed for F-5 Gel, the active mixture of a new contraceptive sponge (Protectaid), which contains Sodium cholate in association with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride. Both cholic acid and the F-5 Gel exert a dose-dependent, in-vitro inhibitory effect (i) on the activity of HIV-1 associated reverse transcriptase in an acellular system and (ii) on the potential of HIV-1 efficiently to infect human lymphocytes. During 12 months use, the contraceptive efficacy of the 'Protectaid' sponge was 100% in 20 young women who had chosen this method for reasons of both contraception and anti-sexually transmitted disease. No side-effects were recorded throughout this period. Cervical cultures at 6-month intervals showed the presence of Mycoplasma hominis and Candida albicans in one or two cases. The combined spermicidal and anti-HIV properties of cholic acid reported in this paper and used in the 'Protectaid' sponge offer a new and modern protective method of contraception.|
Diamond & Related Materials, 2007, 16(1):12-15.
|Electrochemical behavior of sodium cholate and deoxycholate on an electrode modified with multi-walled carbon nanotubes (MWNTs) linked up with cyclodextrin[Reference: WebLink]|
|The electrochemical behavior of Sodium cholate (CA) and deoxycholate (DCA) was investigated on ITO electrodes coated with β-cyclodextrin (β-CD) modified multi-walled carbon nanotubes (MWNTs) in aqueous solution. β-CD modified MWNTs (MWNT–CDs) showed electrocatalytic effect on the reduction of CA, while electrochemical response of DCA was not observed. To further understand the mechanism of the electrochemical process, the electrochemical behavior of CA and DCA on bare ITO electrode and the electrode modified with MWNTs possessing carboxyl groups (MWNT–COOHs) was also discussed. The results indicate that the electrochemical response of CA can be improved through the use of carbon nanotubes. The introduction of cyclodextrin moieties enhances the selectivity of the electrodes to CA and DCA.|