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    Sterigmatocystin
    Sterigmatocystin
    Information
    CAS No. 10048-13-2 Price
    Catalog No.CFN96575Purity>=98%
    Molecular Weight324.29Type of CompoundXanthones
    FormulaC18H12O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    Sterigmatocystin Description
    Source: From grains.
    Biological Activity or Inhibitors: 1. Sterigmatocystin , a mycotoxin commonly found in foodstuff and feedstuff, has been shown to be a carcinogenic mycotoxin in animal models.
    2. Sterigmatocystin shows different toxicological, mutagenic and carcinogenic effects in animals and has been recognized as a 2B carcinogen (possible human carcinogen) by International Agency for Research on Cancer.
    3. Sterigmatocystin has certain inhibiting effects on the secretion of IL-2 of human peripheral blood mononuclear cells (HPBMc) in vitro.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0837 mL 15.4183 mL 30.8366 mL 61.6732 mL 77.0915 mL
    5 mM 0.6167 mL 3.0837 mL 6.1673 mL 12.3346 mL 15.4183 mL
    10 mM 0.3084 mL 1.5418 mL 3.0837 mL 6.1673 mL 7.7091 mL
    50 mM 0.0617 mL 0.3084 mL 0.6167 mL 1.2335 mL 1.5418 mL
    100 mM 0.0308 mL 0.1542 mL 0.3084 mL 0.6167 mL 0.7709 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Sterigmatocystin References Information
    Citation [1]

    Wei Sheng Yan Jiu. 2002 Apr;31(2):112-4.

    Effects of sterigmatocystin on interleukin-2 secretion of human peripheral blood mononuclear cells in vitro.[Pubmed: 12561545]
    Sterigmatocystin (ST) is one of predominant contaminating mycotoxins in foodstuffs and grains of high incidence areas of malignant tumors in China. The effect of ST on interleukin-2 (IL-2) secretion of human peripheral blood mononuclear cells (HPBMc) in vitro was determined with enzyme-linked immunosorbent assay (ELISA) method to explore its putative effects on human immune function. ELISA analysis revealed that ST treatment generally showed negative effects on the IL-2 secretion of HPBMc in vitro. As the ST concentration changes, the inhibiting effects were different. The inhibiting effects at low concentrations (0.03125-0.125 mg/L) and high concentrations (1-2 mg/L) were stronger than the other concentrations(P < 0.05). The time-effect analysis (ST 1 mg/L) showed that inhibiting effects of ST on IL-2 secretion of HPBMc could be seen to a variable degree from 1 to 64 h after ST treatment, while a significant time-effect correlation could be found from 8 to 64 h (r = 0.822, P < 0.05). The results obtained in present study showed that ST has certain inhibiting effects on the secretion of IL-2 of HPBMc in vitro.
    Citation [2]

    Mol Nutr Food Res. 2011 May;55(5):749-60.

    Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells.[Pubmed: 21287681]
    Sterigmatocystin (ST), a mycotoxin commonly found in foodstuff and feedstuff, has been shown to be a carcinogenic mycotoxin in animal models. Many studies showed that the high level of ST contamination in grains might be related to the high incidence of gastric carcinoma in rural areas of China. However, up to now, the potential effects of ST on human gastric epithelium cells remain largely unknown. In this study, we explored the effects of ST on cell-cycle distribution and the regulatory mechanism in immortalized human gastric epithelium cells (GES-1). This study demonstrates that JNK, ERK and PI3K/AKT/mTOR pathways participated in the G2 arrest induced by ST through the deregulation of CyclinB1, Cdc2 and Cdc25C. It may play some roles in the gastric carcinogenesis in ST exposure populations.
    Citation [3]

    Mol Nutr Food Res. 2010 Jan;54(1):136-47.

    Sterigmatocystin: occurrence in foodstuffs and analytical methods--an overview.[Pubmed: 19998385]
    Sterigmatocystin (STC) is a mycotoxin produced by fungi of many different Aspergillus species. Other species such as Bipolaris, Chaetomium, Emiricella are also able to produce STC. STC producing fungi were frequently isolated from different foodstuffs, while STC was regularly detected in grains, corn, bread, cheese, spices, coffee beans, soybeans, pistachio nuts, animal feed and silage. STC shows different toxicological, mutagenic and carcinogenic effects in animals and has been recognized as a 2B carcinogen (possible human carcinogen) by International Agency for Research on Cancer. There are more than 775 publications available in Scopus (and more than 505 in PubMed) mentioning STC, but there is no summary information available about STC occurrence and analysis in food. This review presents an overview of the worldwide information on the occurrence of STC in different foodstuffs during the last 40 years, and describes the progress made in analytical methodology for the determination of STC in food.
    Citation [4]

    Carcinogenesis. 1981;2(10):945-9.

    Cytotoxic and mutagenic effects of sterigmatocystin on cultured Chinese hamster cells.[Pubmed: 7296761]
    Cytotoxic and mutagenic effect of Sterigmatocystin (STC), a carcinogenic mycotoxin, on cultured Chinese hamster cells were investigated in the presence or absence of a metabolic activation system. STC directly applied to the cells induced cytotoxicity and drug-resistant mutations in a time- and concentration-dependent manner. Analyses of the effects of STC showed that treatment for shorter periods was more effective than that for longer periods. The presence of an activation system, cytotoxic and mutagenic effects of STC were strongly enhanced, and 1% of the microsome fraction was most efficient in inducing the effects. Analyses by equitoxic comparison showed that there was little difference in mutagenic activity between the direct treatment and the treatment using an activation system.