Vitexin 7-glucoside | CAS:35109-95-6 | Manufacturer ChemFaces

Vitexin 7-glucoside

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.

In vitro:

European Journal of Medicinal Chemistry, 2006, 41(5):605-610.

Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink]

A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
METHODS AND RESULTS:
In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and Vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
CONCLUSIONS:
This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates.

Vitexin 7-glucoside Description

Source:	The fruits of Crataegus pinnatifida Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Vitexin 7-glucoside
Price:
CAS No.:	35109-95-6
Catalog No.:	CFN70343
Molecular Formula:	C₂₇H₃₀O₁₅
Molecular Weight:	594.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Crataegus pinnatifida Bge.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6821 mL	8.4104 mL	16.8209 mL	33.6417 mL	42.0521 mL
5 mM	0.3364 mL	1.6821 mL	3.3642 mL	6.7283 mL	8.4104 mL
10 mM	0.1682 mL	0.841 mL	1.6821 mL	3.3642 mL	4.2052 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL

CFN98601	Vitexin	3681-93-4	432.4	C₂₁H₂₀O₁₀
CFN93575	Vitexin argininate	N/A	606.6	C₂₇H₃₄N₄O₁₂
CFN70343	Vitexin 7-glucoside	35109-95-6	594.5	C₂₇H₃₀O₁₅
CFN90654	Vitexin 2''-O-p-coumarate	59282-55-2	578.5	C₃₀H₂₆O₁₂
CFN90500	4'-O-Methylvitexin	2326-34-3	446.12	C₂₂H₂₂O₁₀
CFN95303	Margaritene	64271-10-9	592.6	C₂₈H₃₂O₁₄
CFN95510	Sophoraflavone A	105594-08-9	562.5	C₂₇H₃₀O₁₃
CFN98177	Vitexin-2''-O-rhamnoside	64820-99-1	578.52	C₂₇H₃₀O₁₄
CFN70421	Vitexin 2''-glucoside	61360-94-9	594.5	C₂₇H₃₀O₁₅
CFN96447	Vitexin 2''-O-(4'''-O-acetyl)rhamnoside	80537-98-0	620.56	C₂₉H₃₂O₁₅