1. Caffeine has anxiolytic-like activity, can have both positive and negative effects on anxiety.
2. Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.
1. Galanolactone shows cytotoxic activity .
2. Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors.
3. Galanolactone exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes.
4. Galanolactone has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
1. Alpha-Yohimbine is strong selective 2-adrenoceptor antagonist.
2. Alpha-Yohimbine possess aphrodisiac effect.
3. Alpha-Yohimbine is a 5-HT1A receptor agonist.
1. Dendrobine, isolated from Dendrobium nobile, an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.
2. Dendrobine has antitumor activity, it can inhibit the growth of A549 cells through inducing apoptosis, which is partially dependent on mitochondrial-mediated pathway; dendrobine treatment decreased mitochondrial membrane potential (MMP), improved the expression of Bax and inhibited the expression of Bcl-2.
3. Dendrobine possesses antiviral activity against influenza A viruses, including A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2) with IC50 values of 3.39 ± 0.32, 2.16 ± 0.91, 5.32 ± 1.68 ug/mL, respectively.
1. Yohimbine is an alkaloid with stimulant and aphrodisiac effects, helping with erections, particularly in those whose erectile dysfunction is due to psychological causes.
2. Yohimbine hydrochloride is an antagonist to xylazine hydrochloride-ketamine hydrochloride immobilization of white-tailed deer.
3. Yohimbine hydrochloride can block alpha 2-adrenergic and dopamine receptors and stimulate serotonergic receptors, it may possible be an antagonist for fescue toxicosis.
4. Yohimbine hydrochloride, a noradrenaline agonist, can facilitate fear extinction, it is thought that the mechanism of enhanced emotional memory is stimulated through elevated noradrenaline levels.