|A unique collection of 41 natural compounds used for Anti-diabetic research|
|Catalog No:||B544|| Anti-diabetic Compound Library
|Size:||1mg/well * 41 Compounds|
2mg/well * 41 Compounds
1. Chrysophanol 8-O-beta-D-glucoside has cytotoxic activity.
2. Chrysophanol 8-O-beta-D-glucoside is potential antioxidant.
3. Chrysophanol 8-O-beta-D-glucoside shows a strong inhibitory effect on HBV DNA release.
1. Genipin is a novel chemical activator of EBV lytic cycle.
2. Genipin is used for choleretic action for liver diseases control.
3. Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.
4. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking, can be used as a regulating agent for drug delivery, as the raw material for gardenia blue pigment preparation.
5. Genipin blocks the action of the enzyme uncoupling protein 2. Uncoupling protein-2 (UCP2), is a UCP2 inhibitor.the chemical inhibition of UCP2 with genipin sensitizes multidrug-resistant cancer cells to cytotoxic agents.
1. Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload induced redox-inflammatory damage.
2. Synthetic Secoisolariciresinol Diglucoside at 25 mg/kg b.w., exerts anti hyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.
3. Secoisolariciresinol Diglucoside has renoprotective effects in HFD/STZ-induced DN in rats through correction of hyperglycemia.
(1) Attenuation of oxidative/nitrosative stress markers;
(2) Downregulation of renal expressions of inflammatory markers NF-κB, TNF-α, and iNOS;
(3) Along with upregulation of renal expressions of antiapoptotic markers survivin and Bcl-2;
(4) Maintain tissue function which results in improving the sensitivity and response of target cells in STZ-induced diabetic rats to insulin.
|CFN99756||Ginsenoside Compound K
1. Ginsenoside compound K (C-K) could be a potentially effective anti-colorectal cancer agent.
2. C-K showed significant anti-proliferative effects in HCT-116 and SW-480 cells at concentrations of 30-50 µM.
3. C-K could be a potential drug for pediatric AML intervention and to improve the outcome of pediatric AML treatment, via significant G1 cell cycle arrest and apoptosis.
4. C-K reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins and inhibited the activation of NF-kB, a nuclear transcription factor.
5. Ginsenoside Rb1 can be transformed to CK by intestinal bacteria, and C-K may be effective against inflammation.
1. Lupenone effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
2. The in vitro trypanocidal activity of a 1 : 4 mixture of Lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46).