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  • Bioactive Products
    Anti-diabetic Compound Library
    A unique collection of 41 natural compounds used for Anti-diabetic research
    Catalog No: B544 Anti-diabetic Compound Library
    Screening Details
    Size: 1mg/well * 41 Compounds
    2mg/well * 41 Compounds
    Catalog No. Information
    CFN99410 Chrysophanol 8-O-glucoside

    1. Chrysophanol 8-O-beta-D-glucoside has cytotoxic activity.
    2. Chrysophanol 8-O-beta-D-glucoside is potential antioxidant.
    3. Chrysophanol 8-O-beta-D-glucoside shows a strong inhibitory effect on HBV DNA release.
    CFN99142 Genipin

    1. Genipin is a novel chemical activator of EBV lytic cycle.
    2. Genipin is used for choleretic action for liver diseases control.
    3. Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.
    4. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking, can be used as a regulating agent for drug delivery, as the raw material for gardenia blue pigment preparation.
    5. Genipin blocks the action of the enzyme uncoupling protein 2. Uncoupling protein-2 (UCP2), is a UCP2 inhibitor.the chemical inhibition of UCP2 with genipin sensitizes multidrug-resistant cancer cells to cytotoxic agents.
    CFN99722 Secoisolariciresinol Diglucoside

    1. Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload induced redox-inflammatory damage.
    2. Synthetic Secoisolariciresinol Diglucoside at 25 mg/kg b.w., exerts anti hyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.
    3. Secoisolariciresinol Diglucoside has renoprotective effects in HFD/STZ-induced DN in rats through correction of hyperglycemia.
    (1) Attenuation of oxidative/nitrosative stress markers;
    (2) Downregulation of renal expressions of inflammatory markers NF-κB, TNF-α, and iNOS;
    (3) Along with upregulation of renal expressions of antiapoptotic markers survivin and Bcl-2;
    (4) Maintain tissue function which results in improving the sensitivity and response of target cells in STZ-induced diabetic rats to insulin.
    CFN99756 Ginsenoside Compound K

    1. Ginsenoside compound K (C-K) could be a potentially effective anti-colorectal cancer agent.
    2. C-K showed significant anti-proliferative effects in HCT-116 and SW-480 cells at concentrations of 30-50 µM.
    3. C-K could be a potential drug for pediatric AML intervention and to improve the outcome of pediatric AML treatment, via significant G1 cell cycle arrest and apoptosis.
    4. C-K reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins and inhibited the activation of NF-kB, a nuclear transcription factor.
    5. Ginsenoside Rb1 can be transformed to CK by intestinal bacteria, and C-K may be effective against inflammation.
    CFN99681 Lupenone

    1. Lupenone effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
    2. The in vitro trypanocidal activity of a 1 : 4 mixture of Lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4 μ g/mL, FIC = 0.46).