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  • Bioactive Products
    Catalog No. Information
    CFN92173 Cyanidin-3-O-sambubioside chloride

    1. Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NFκB activity.
    2. Cyanidin-3-O-sambubioside chloride inhibits the enzyme activity by competing with the substrate for the active site.
    3. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging property.
    4. Cyanidin-3-O-sambubioside chloride is highly water-soluble and is easily degraded by hydrolysis and /or hydrogenation at temperatures >40°C.
    CFN92186 Salvicine

    1. Salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin.
    2. Specificity of Salvicine and diversity of anticancer agents in the mechanism of interference with telomerase and the telomere system.
    3. Salvicine has potent anti-angiogenic activity through the inhibition on the sequential angiogenic cascades: proliferation, migration and tube formation and is associated with influence on the expression of bFGF of tumor cell.
    4. Salvicine has antimetastatic activity and shed new light on the complex roles of ROS and downstream signaling molecules, particularly p38 MAPK, in the regulation of integrin function and cell adhesion.
    CFN93276 Irigenin

    1. Irigenin, tectorigenin, iristectorigenin A and irisflorentin are α-glucosidase inhibitors.
    2. Irigenin prevents metastatic capacity of lung cancer cells by selectively blocking Extra Domain A.
    3. Irigenin has antiinflammatory effects, it can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect.
    4. Irigenin, irilone, and iriskashmirianin display moderate activity as inducers of NAD(P)H:quinone reductase (QR) in cultured mouse Hepa 1c1c7 cells.
    CFN93610 alpha-Carotene

    1. alpha-Carotene has a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
    2. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO.
    3. alpha-Carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice.
    CFN93581 Perillyl alcohol

    1. Perillyl alcohol has potential chemopreventive activity against colon carcinogenesis, the chemopreventive activity of perillyl alcohol is mediated through the tumor cell loss by apoptosis.
    2. Perillyl alcohol inhibits umor incidence and multiplicity, average tumor size and inhibits UVB-induced AP-1 transactivation in both cultured human keratinocytes and transgenic mice that stably express a luciferase reporter driven by AP-1 elements, suggests that perillyl alcohol may be used for chemoprevention of human skin cancer, and that inhibition of AP-1 activity is functionally related to inhibition of skin carcinogenesis.
    3. Perillyl alcohol can suppress antigen-induced immune responses in the lung, it could be a novel preventive or therapeutic option for immunologic lung disorders such as asthma with minimal side effects.
    4. Perillyl alcohol pre-treatment significantly ameliorates ethanol induced acute liver injury possibly by inhibition of lipid peroxidation, replenishment of endogenous enzymatic and non-enzymatic defense system, downregulation of TNF-α as well as NF&kappa-B.
    5. Perillyl alcohol has antileukemia activity, which-mediated cell cycle arrest precedes apoptosis and raises the possibility that that the primary effect of perillyl alcohol is to induce G0/G1 arrest with apoptosis being a consequence of the growth arrest.