1. Colchicine has anti-cancer activity.
2. Colchicine is a anti-gout agent.
3. Colchicine is used to treat familial Mediterranean fever.
4. Colchicine is used as an anti-inflammatory agent for long-term treatment of Behçet's disease.
5. Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules.
6. Colchicine is also used for constipation-predominant irritable bowel syndrome in women, and for treatment of severe or persistent aphthous stomatitis (canker sores).
1. Methyl protodioscin has antitumor property.
2. Methyl protodioscin potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides.
3. Methyl protodioscin induced apoptotic process in human A549 cells is closely associated with Mitochondrial membrane potential, mitochondrial cytochrome c and caspase-3 .
4. Methyl protodioscin showed strong cytotoxicity against most cell lines from solid tumors with GI50 ≤10.0 microM.
5. Methyl protodioscin could block the volt dependent form calcium channel in cellular membrane, and up-regulate the function of sodium pump and calcium pump, so that it could remain low calcium in the internal environment in cardiomyocytes.
1. Theobromine may have therapeutic potential for diabetic nephropathy, by reducing kidney ECM accumulation in diabetic.
2. Theobromine independently increased serum HDL-cholesterol concentrations by 0.16 mmol/L.
3. Theobromine at normal intake ranges may contribute to the positive effects of chocolate, but at higher intakes, effects become negative.
1. Cornin induces angiogenesis in vitro via a programmed PI3K/Akt/eNOS/VEGF signaling axis.
2. Cornin has protective potential against cerebral ischemia injury and its protective effects may be due to amelioration of cerebral mitochondrial function and its antioxidant property.
1. Lasiocarpine has antimitotic action.