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Download 3-Epidehydrotumulosic acid : Manual COA MSDS
More articles cited ChemFaces products.
Mol Med Rep.2014 May;9(5):1653-9.Inflammation.2015 Feb;38(1):445-55. Hindawi Publishing Corporation2015 July 30Molecules 2016, 21(6), 780; 2016 Jun 17;21(6).
International Journal of Mol. Med.2015 Mar 6.Arch Pharm Res.2014 Oct 18.BMC Complement Altern Med.2014 Jul 14;14:242.J. of Pha. and Biomed. Analysis25 Jan. 2016
J Ethnopharmacol. 2016 Jul 12.PhytomedicineFeb. 11. 2016ARPN Journal of Eng.& Applied Sci.4, Feb. 2016
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3-Epidehydrotumulosic acid Description
||The root of Wolfiporia cocos (Schw.) Ryv.
|1. 3-Epidehydrotumulosic acid has inhibitory activity against AAPH-induced lysis of red blood cells.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better
solubility within lower of Concentrations.
3-Epidehydrotumulosic acid References Information
J Nat Prod. 2002 Apr;65(4):462-5.
|Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.[Pubmed: 11975480]|
|The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; poricoic acid G) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid H) on the basis of spectroscopic methods. These two, and eight other known compounds isolated from the sclerotium, poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-Epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-Epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.
Phytother Res. 2003 Feb;17(2):160-2.
|Inhibitory effects of triterpenes isolated from Hoelen on free radical-induced lysis of red blood cells.[Pubmed: 12601680]|
|Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis. In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-Epidehydrotumulosic acid, 3beta-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-o-acetyl-16 alpha -hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.