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Cynoglossamine
Cynoglossamine
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Product Name Cynoglossamine
Price:
CAS No.: 120193-39-7
Catalog No.: CFN00257
Molecular Formula: C24H31NO7
Molecular Weight: 445.51 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Cynoglossum amabile
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
Cynoglossamine Description
Source: The herbs of Cynoglossum amabile
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2446 mL 11.2231 mL 22.4462 mL 44.8924 mL 56.1155 mL
5 mM 0.4489 mL 2.2446 mL 4.4892 mL 8.9785 mL 11.2231 mL
10 mM 0.2245 mL 1.1223 mL 2.2446 mL 4.4892 mL 5.6115 mL
50 mM 0.0449 mL 0.2245 mL 0.4489 mL 0.8978 mL 1.1223 mL
100 mM 0.0224 mL 0.1122 mL 0.2245 mL 0.4489 mL 0.5612 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 1989 Jan-Feb;52(1):109-18.
Pyrrolizidine alkaloids from Cynoglossum creticum. Synthesis of the pyrrolizidine alkaloids echinatine, rinderine, and analogues.[Pubmed: 2597280]
Reinvestigation of Cynoglossum creticum led to the isolation of the previously reported echinatine [1] and heliosupine [2] as well as rinderine [3], 7-angelylheliotridine [4] and a new alkaloid, Cynoglossamine [5].
METHODS AND RESULTS:
The structures have been determined by spectral means (ir, ms, 1H-13C HETCOR nmr), comparison with literature data and authentic samples, and/or syntheses. In addition, 1 and all three of its isomers 3, 6, and 7 and other semisynthetic analogues (8-13) were prepared and characterized.
CFN00255Echinatine480-83-1299.37C15H25NO5
CFN00256Echinatine N-oxide20267-93-0315.36C15H25NO6
CFN00257Cynoglossamine120193-39-7445.51C24H31NO7
CFN00258Rinderine6029-84-1299.37C15H25NO5
CFN00470Rinderine N-oxide137821-16-0315.4C15H25NO6
CFN00259Echiumine633-16-9381.47C20H31NO6
CFN00260Myoscorpine82535-76-0381.47C20H31NO6
CFN00261Symlandine74410-74-5381.47C20H31NO6
CFN00251Curassavine68385-70-6299.41C16H29NO4
CFN00254Echimidine520-68-3397.47C20H31NO7
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