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    Dichotomin
    Information
    CAS No. 53093-47-3 Price
    Catalog No.CFN90703Purity>=98%
    Molecular Weight1195.34Type of CompoundSteroids
    FormulaC57H94O26Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Description: Reference standards.
    Dichotomin Description
    Source: The rhizomes of Paris yunnanensis Franch.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

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    IF=14.548(2019)

    PMID: 29149595

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    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.8366 mL 4.1829 mL 8.3658 mL 16.7316 mL 20.9146 mL
    5 mM 0.1673 mL 0.8366 mL 1.6732 mL 3.3463 mL 4.1829 mL
    10 mM 0.0837 mL 0.4183 mL 0.8366 mL 1.6732 mL 2.0915 mL
    50 mM 0.0167 mL 0.0837 mL 0.1673 mL 0.3346 mL 0.4183 mL
    100 mM 0.0084 mL 0.0418 mL 0.0837 mL 0.1673 mL 0.2091 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    《Chinese Journal of Natural Medicines》 2009-05
    Biotransformation of Dichotomin by Pectinex BE XXL[Reference: WebLink]
    To study of structural modification in steroidal saponin by biotransformation technology.
    METHODS AND RESULTS:
    Structural modification was carried out of glycosyl residues of Dichotomin at C-3 position by Pectinex BE XXL(PBX).Cytotoxicity against HL-60 cells of all products was investigated. The PBX could hydrolyze the glycosyl residues of Dichotomin one-by-one to produce nine transformed compounds.The transformed product(mixture) and four secondary spirostanosides among them exhibited cytotoxicity.Compounds P5,P6 and P7 with α-1,2 end-rhamnosyl residues showed a potential cytotoxic effect on HL-60 cells;P8 with α-1,4 end-rhamnosyl residue had a weak effect on HL-60 cells.Dichotomin,secondary furostanosides and aglycone were not cytotoxic.
    CONCLUSIONS:
    PBX has various hydrolyzation to the glycosidic bonds of Dichotomin.Nine obtained transformed compounds widen steroidal saponin library.Meanwhile,screening activity affords data for further pharmacological study.