Futoenone | CAS:19913-01-0 | Manufacturer ChemFaces

Futoenone

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.

Targets:

PAFR

In vitro:

The Journal of Chinese medicine,2002,13(3):159-70.

Some Immunomodulatory Principles Isolated from Piper Kadsura[Reference: WebLink]

METHODS AND RESULTS:
From the ethanol extract of the stem of Piper kadsura (Piperaceae), seven compounds-futoquinol; Futoenone; (+)-crotepoxide; galgravin; (-)galbelgin; piperlactam S and piperolactam B were isolated, identified and tested for immunopharmacological activities with human mononuclear cells (HMNC) being used as target cells and cell proliferation determined by 3Hthymidine uptake.
CONCLUSIONS:
The results indicated that compounds futoquinol, galgravin, piperlactam S and piperolactam B potently inhibited HMNC proliferation and interferon-g production. Therefore immunosup pressive mechanisms might involve the impairment of cytokines production.

Bioorganic & Medicinal Chemistry Letters,1995,5(15):1637-42.

Inhibition of metalloproteinase by futoenone derivatives[Reference: WebLink]

METHODS AND RESULTS:
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases. The molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes.

Futoenone Description

Source:	The stems of Piper kadsura.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Futoenone
Price:
CAS No.:	19913-01-0
Catalog No.:	CFN96370
Molecular Formula:	C₂₀H₂₀O₅
Molecular Weight:	340.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The stems of Piper kadsura.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-platelet aggregation Compound Library Antagonists Compound Library Lignans Compound Library PAFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9377 mL	14.6886 mL	29.3772 mL	58.7544 mL	73.443 mL
5 mM	0.5875 mL	2.9377 mL	5.8754 mL	11.7509 mL	14.6886 mL
10 mM	0.2938 mL	1.4689 mL	2.9377 mL	5.8754 mL	7.3443 mL
50 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.1751 mL	1.4689 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.5875 mL	0.7344 mL

CFN96359	4-O-Demethylisokadsurenin D	89104-59-6	342.4	C₂₀H₂₂O₅
CFN96358	4-O-Demethylkadsurenin D	127179-70-8	342.4	C₂₀H₂₂O₅
CFN96308	Kadsurenin D	140669-89-2	356.4	C₂₁H₂₄O₅
CFN96322	Isokadsurenin D	147976-35-0	356.4	C₂₁H₂₄O₅
CFN96313	Denudadione C	61240-34-4	340.4	C₂₀H₂₀O₅
CFN96257	Denudanolide A	288259-72-3	356.4	C₂₀H₂₀O₆
CFN97875	5-Allyl-3-methoxy-6-methyl-7-(3,4,5-trimethoxyphenyl)bicyclo[3.2.1]oct-3-ene-2,8-dione	106894-43-3	386.4	C₂₂H₂₆O₆
CFN96370	Futoenone	19913-01-0	340.4	C₂₀H₂₀O₅
CFN97307	Maglifloenone	82427-77-8	386.4	C₂₂H₂₆O₆