|Source:||The stem of Piper kadsura.|
|Biological Activity or Inhibitors:||1. Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes.
2. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.9377 mL||14.6886 mL||29.3772 mL||58.7544 mL||73.443 mL|
|5 mM||0.5875 mL||2.9377 mL||5.8754 mL||11.7509 mL||14.6886 mL|
|10 mM||0.2938 mL||1.4689 mL||2.9377 mL||5.8754 mL||7.3443 mL|
|50 mM||0.0588 mL||0.2938 mL||0.5875 mL||1.1751 mL||1.4689 mL|
|100 mM||0.0294 mL||0.1469 mL||0.2938 mL||0.5875 mL||0.7344 mL|
The Journal of Chinese medicine,2002,13(3):159-70.
|Some Immunomodulatory Principles Isolated from Piper Kadsura[Reference: WebLink]|
|From the ethanol extract of the stem of Piper kadsura (Piperaceae), seven compounds-futoquinol; Futoenone; (+)-crotepoxide; galgravin; (-)galbelgin; piperlactam S and piperolactam B were isolated, identified and tested for immunopharmacological activities with human mononuclear cells (HMNC) being used as target cells and cell proliferation determined by 3Hthymidine uptake. The results indicated that compounds futoquinol, galgravin, piperlactam S and piperolactam B potently inhibited HMNC proliferation and interferon-g production. Therefore immunosup pressive mechanisms might involve the impairment of cytokines production.|
Bioorganic & Medicinal Chemistry Letters,1995,5(15):1637-42.
|Inhibition of metalloproteinase by futoenone derivatives[Reference: WebLink]|
|Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases. The molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes.|
EP 0574510 A4[P].1994.
|Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors[Reference: WebLink]|
|Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and Futoenone variety exhibit both PAF and 5-lipoxygenase antagonist activity.|