Science | Nature | Cell | View More
Natural Products
Kanshone B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Kanshone B
Price:
CAS No.: 115370-61-1
Catalog No.: CFN89423
Molecular Formula: C15H22O4
Molecular Weight: 266.33 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The rhizomes and roots of Nardostachys chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Toronto (Canada)
  • University of British Columbia (Canada)
  • Amity University (India)
  • University of Medicine and Phar... (Romania)
  • University of Fribourg (Switzerland)
  • Institute of Pathophysiology Me... (Austria)
  • Uniwersytet Gdański (Poland)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Griffith University (Australia)
  • Cornell University (USA)
  • Tohoku University (Japan)
  • More...
Package
Featured Products
Neohesperidin

Catalog No: CFN99125
CAS No: 13241-33-3
Price: $40/20mg
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
Salvianolic acid A

Catalog No: CFN99161
CAS No: 96574-01-5
Price: $128/20mg
Eleutheroside E

Catalog No: CFN99984
CAS No: 39432-56-9
Price: $50/20mg
Gomisin N

Catalog No: CFN90125
CAS No: 69176-52-9
Price: $218/20mg
Hesperetin

Catalog No: CFN98842
CAS No: 520-33-2
Price: $40/20mg
Vaccarin

Catalog No: CFN90131
CAS No: 53452-16-7
Price: $30/20mg
Meloside A

Catalog No: CFN90132
CAS No: 60767-80-8
Price: $238/5mg
Mesaconitine

Catalog No: CFN99199
CAS No: 2752-64-9
Price: $98/20mg
Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kanshone B shows inhibitory activity against LPS-induced NO production with the IC(50) value of 4.6-21.6 uM.
Targets: NO
In vitro:
Bioorg Med Chem Lett. 2012 Jan 1;22(1):706-8.
Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.[Pubmed: 22079762]

METHODS AND RESULTS:
The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), Kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR.
CONCLUSIONS:
Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC(50) values of 4.6-21.6 μM.
Kanshone B Description
Source: The rhizomes and roots of Nardostachys chinensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Epimedin B1

Catalog No: CFN95017
CAS No: 133137-58-3
Price: $268/5mg
New compound 13

Catalog No: CFN95374
CAS No: N/A
Price: $318/5mg
Dioscoreside E

Catalog No: CFN95346
CAS No: 435321-73-6
Price: $318/5mg
Nortrachelogenin-5'-C-beta-glucosi...

Catalog No: CFN95251
CAS No: 858127-39-6
Price: $318/10mg
Oxyphyllol B

Catalog No: CFN95575
CAS No: 226546-99-2
Price: $/mg
(3E,5E,11E)-tridecatriene-7,9-diyn...

Catalog No: CFN95191
CAS No: N/A
Price: $318/5mg
Ganolucidic acid E

Catalog No: CFN95536
CAS No: 114567-50-9
Price: $318/5mg
Isonemerosin

Catalog No: CFN95008
CAS No: 181524-79-8
Price: $268/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7547 mL 18.7737 mL 37.5474 mL 75.0948 mL 93.8685 mL
5 mM 0.7509 mL 3.7547 mL 7.5095 mL 15.019 mL 18.7737 mL
10 mM 0.3755 mL 1.8774 mL 3.7547 mL 7.5095 mL 9.3869 mL
50 mM 0.0751 mL 0.3755 mL 0.7509 mL 1.5019 mL 1.8774 mL
100 mM 0.0375 mL 0.1877 mL 0.3755 mL 0.7509 mL 0.9387 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Neohesperidin

Catalog No: CFN99125
CAS No: 13241-33-3
Price: $40/20mg
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
Salvianolic acid A

Catalog No: CFN99161
CAS No: 96574-01-5
Price: $128/20mg
Eleutheroside E

Catalog No: CFN99984
CAS No: 39432-56-9
Price: $50/20mg
Gomisin N

Catalog No: CFN90125
CAS No: 69176-52-9
Price: $218/20mg
Hesperetin

Catalog No: CFN98842
CAS No: 520-33-2
Price: $40/20mg
Vaccarin

Catalog No: CFN90131
CAS No: 53452-16-7
Price: $30/20mg
Meloside A

Catalog No: CFN90132
CAS No: 60767-80-8
Price: $238/5mg
Mesaconitine

Catalog No: CFN99199
CAS No: 2752-64-9
Price: $98/20mg
Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg
Tags: buy Kanshone B | Kanshone B supplier | purchase Kanshone B | Kanshone B cost | Kanshone B manufacturer | order Kanshone B | Kanshone B distributor