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    Luteosporin
    Information
    CAS No. 2530-39-4 Price
    Catalog No.CFN98567Purity>=98%
    Molecular Weight546.44Type of CompoundQuinones
    FormulaC28H18O12Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 1. Luteosporin and xanthomegnin are pigments, they are suspected to be genotoxic carcinogens.
    2. Luteosporin inhibits porcine pancreatic phospholipase A2 (PLA2) with Ki values of 12.8 microM.
    Luteosporin Description
    Source: The body of Cordyceps sienesis (Berkeley) Saccardo
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29149595

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    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

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    J Cell Biochem. 2018 Feb;119(2):2231-2239.
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    Phytomedicine. 2018 Feb 1;40:37-47.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.83 mL 9.1501 mL 18.3003 mL 36.6005 mL 45.7507 mL
    5 mM 0.366 mL 1.83 mL 3.6601 mL 7.3201 mL 9.1501 mL
    10 mM 0.183 mL 0.915 mL 1.83 mL 3.6601 mL 4.5751 mL
    50 mM 0.0366 mL 0.183 mL 0.366 mL 0.732 mL 0.915 mL
    100 mM 0.0183 mL 0.0915 mL 0.183 mL 0.366 mL 0.4575 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Luteosporin References Information
    Citation [1]

    J Antibiot (Tokyo). 1985 Jun;38(6):706-12.

    Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties.[Pubmed: 3839502]
    Plastatin and the known fungal metabolite, Luteosporin, have been isolated from fermentations of Penicillium chermesinum as inhibitors of porcine pancreatic phospholipase A2 (PLA2). Structure 1 for plastatin was deduced from its spectroscopic properties. Plastatin and Luteosporin inhibited pancreatic PLA2 competitively with Ki values of 0.89 microM and 12.8 microM, respectively. PLA2 preparations from Naja naja and Crotalus adamanteus were not significantly inhibited by plastatin and Luteosporin.
    Citation [2]

    Cancer Res. 1984 Jul;44(7):2918-23.

    Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.[Pubmed: 6722817]
    Twenty-eight mycotoxins were studied in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6- dimethoxysterigmatocystin , versicolorins A and B, averufin , xanthomegnin , Luteosporin , and chrysazin , as well as by the carcinogenic myocotoxins , aflatoxin B1, sterigmatocystin, luteoskyrin , ochratoxin A, azaserine, mitomycin C, and actinomycin D. The positive results with compounds of unknown carcinogenicity suggest that they are possibly genotoxic carcinogens. The carcinogenic mycotoxins, penicillic acid, patulin, griseofulvin, and rugulosin , which did not elicit repair synthesis may be nongenotoxic carcinogens.
    Citation [3]

    Mutat Res. 1983 Oct;122(1):29-34.

    Genotoxicity of quinone pigments from pathogenic fungi.[Pubmed: 6621592]
    The genotoxicity and mutagenicity of several kinds of quinone pigments from pathogenic fungi were examined by means of the hepatocyte primary culture (HPC)/DNA repair test and of Ames test with TA98 and TA100. Clear genotoxicity of the two quinone chemicals, xanthomegnin and Luteosporin were observed in the HPC/DNA repair test, though definite mutagenicity was not detected in the Salmonella microsome test. These two pigments are thus suspected to be genotoxic carcinogens.